Differential Mortality Risks Associated With PM<sub>2.5</sub> Components A Multi-Country, Multi-City Study

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dc.coverageDOI: 10.1097/EDE.0000000000001455
dc.creatorMasselot, Pierre
dc.creatorSera, Francesco
dc.creatorSchneider, Rochelle
dc.creatorKan, Haidong
dc.creatorLavigne, Éric
dc.creatorStafoggia, Massimo
dc.creatorTobias, Aurelio
dc.creatorChen, Hong
dc.creatorBurnett, Richard T.
dc.creatorSchwartz, Joel
dc.creatorZanobetti, Antonella
dc.creatorBell, Michelle L.
dc.creatorChen, Bing Yu
dc.creatorGuo, Yue Liang Leon
dc.creatorRagettli, Martina S.
dc.creatorVicedo-Cabrera, Ana Maria
dc.creatorÅström, Christofer
dc.creatorForsberg, Bertil
dc.creatorÍñiguez, Carmen
dc.creatorGarland, Rebecca M.
dc.creatorScovronick, Noah
dc.creatorMadureira, Joana
dc.creatorNunes, Baltazar
dc.creatorDe la Cruz Valencia, César
dc.creatorDiaz, Magali Hurtado
dc.creatorHonda, Yasushi
dc.creatorHashizume, Masahiro
dc.creatorNg, Chris Fook Cheng
dc.creatorSamoli, Evangelia
dc.creatorKatsouyanni, Klea
dc.creatorSchneider, Alexandra
dc.creatorBreitner, Susanne
dc.creatorRyti, Niilo R.I.
dc.creatorJaakkola, Jouni J.K.
dc.creatorMaasikmets, Marek
dc.creatorOrru, Hans
dc.creatorGuo, Yuming
dc.creatorOrtega, Nicolás Valdés
dc.creatorCorrea, Patricia Matus
dc.creatorTong, Shilu
dc.creatorGasparrini, Antonio
dc.date2022
dc.date.accessioned2025-11-18T19:49:21Z
dc.date.available2025-11-18T19:49:21Z
dc.description<p>Background: The association between fine particulate matter (PM<sub>2.5</sub>) and mortality widely differs between as well as within countries. Differences in PM<sub>2.5</sub> composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality. Methods: We applied a 2-stage analysis on data collected from 210 locations in 16 countries. In the first stage, we estimated location-specific relative risks (RR) for mortality associated with daily total PM<sub>2.5</sub> through time series regression analysis. We then pooled these estimates in a meta-regression model that included city-specific logratio-transformed proportions of seven PM<sub>2.5</sub> components as well as meta-predictors derived from city-specific socio-economic and environmental indicators. Results: We found associations between RR and several PM<sub>2.5</sub> components. Increasing the ammonium (NH<sub>4</sub><sup>+</sup>) proportion from 1% to 22%, while keeping a relative average proportion of other components, increased the RR from 1.0063 (95% confidence interval [95% CI] = 1.0030, 1.0097) to 1.0102 (95% CI = 1.0070, 1.0135). Conversely, an increase in nitrate (NO<sub>3</sub><sup>-</sup>) from 1% to 71% resulted in a reduced RR, from 1.0100 (95% CI = 1.0067, 1.0133) to 1.0037 (95% CI = 0.9998, 1.0077). Differences in composition explained a substantial part of the heterogeneity in PM<sub>2.5</sub> risk. Conclusions: These findings contribute to the identification of more hazardous emission sources. Further work is needed to understand the health impacts of PM<sub>2.5</sub> components and sources given the overlapping sources and correlations among many components.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/a7ae2898-67a8-4117-8776-6eb7935f8404
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/56031
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.33 (2022) date: 2022-03-01 nr.2 p.167-175
dc.titleDifferential Mortality Risks Associated With PM<sub>2.5</sub> Components A Multi-Country, Multi-City Studyeng
dc.typeArticleeng
dc.typeArtículospa
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