Adherens junctions and cell polarity: what they are and how they relate to congenital Zika virus syndrome

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dc.coverageDOI: 10.1016/B978-0-12-820267-8.00010-8
dc.creatorBustamante-Barrientos, Felipe A.
dc.creatorHenzi, Roberto
dc.creatorBátiz, Luis Federico
dc.date2021
dc.date.accessioned2025-11-18T19:48:12Z
dc.date.available2025-11-18T19:48:12Z
dc.description<p>Adherens junctions (AJs) comprise cell-cell adhesion complexes that are organized as belt-like structures at the most apical-lateral plasma membrane. In embryonic neural stem and progenitor cells (NSPCs), these junctional complexes are essential for the maintenance of the ventricular lining and the cerebral cytoarchitecture. Several reports in humans and animal models have shown that loss of function of proteins involved in the assembly and/or turnover of AJ components gives rise to a phenotype characterized by disruption of the ventricular zone, increased cell death, and defective corticogenesis. In turn, these models consistently replicate a wide range of defects expressed by vertical transmission of Zika virus (ZIKV), a flavivirus with a high tropism by neural tissues. This chapter summarizes relevant aspects of the structure and function of AJs during brain development and provides novel insights that may contribute to the current knowledge about the etiopathogenesis of congenital ZIKV syndrome (CZS).</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/476e81e1-4e57-4e87-8ee5-d9d1189e973d
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55441
dc.languageeng
dc.publisherElsevier
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceMartin, Colin R., Hollins Martin, Caroline J., Preedy, Victor R., Rajendram, Rajkumar (Ed.), Zika Virus Impact, Diagnosis, Control, and Models: Volume 2: The Neuroscience of Zika Virus, p.111-122. Estados Unidos: Elsevier. [ISBN 978-0-12-820267-8]
dc.subjectBrain cortex
dc.subjectCell-cell adhesion
dc.subjectFlaviviruses
dc.subjectMicrocephaly
dc.subjectN-Cadherin
dc.subjectNeural stem cells
dc.subjectNeurodevelopmental defects
dc.subjectNeurogenesis
dc.subjectZika virus
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAdherens junctions and cell polarity: what they are and how they relate to congenital Zika virus syndromeeng
dc.typeChaptereng
dc.typeCapítulospa
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