Influence of flavonoids on long-term bonding stability on caries-affected dentin

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dc.coverageDOI: 10.1016/j.dental.2020.05.007
dc.creatorDávila-Sánchez, Andrés
dc.creatorGutierrez, Mario Felipe
dc.creatorBermudez, Jorge Pailover
dc.creatorMéndez-Bauer, María Luján
dc.creatorHilgemberg, Bruna
dc.creatorSauro, Salvatore
dc.creatorLoguercio, Alessandro D
dc.creatorArrais, Cesar Augusto Galvão
dc.date2020
dc.date.accessioned2025-11-18T19:47:56Z
dc.date.available2025-11-18T19:47:56Z
dc.description<p>OBJECTIVES: To evaluate the effect of experimental dentin pre-treatment solutions formulated with different flavonoids on microtensile bond strength (μTBS), nanohardness (NH) and ultra-morphological characteristics of artificial caries-affected dentin (CAD) bonded using a universal bonding system.</p><p>METHODS: A microbiological method was used to create an artificial CAD in 91 human molars. Five experimental pre-treatment solutions were created using the following flavonoids: quercetin (QUE); hesperidin (HES); rutin (RUT); naringin (NAR), or proanthocyanidin (PRO). A placebo solution (PLA) with no flavonoids added was also evaluated. The flavonoids or placebo solutions were applied to the CAD prior to the application and photoactivation of a universal adhesive (Scotchbond Universal, 3M Oral Care). A control group (CON), in which only the bonding agent was applied without any flavonoid solution, was also evaluated. A 3-mm-thick block of resin composite (Opallis, FGM) was built up on the flat bonded CAD surfaces and was light-cured following the manufacturer's instructions. Specimens were sectioned to obtain resin-dentin slices and sticks (cross-sectional area of 0.8 mm2). The μTBS, NH, and confocal ultramorphology analysis of resin-dentin interface was evaluated at 24 h and after thermo-cycling aging (25,000 cycles). The results were analyzed using 2-way ANOVA followed by Bonferroni's post hoc test (pre-set α = 0.05).</p><p>RESULTS: The specimens from groups QUE, NAR, and RUT presented greater μTBS values than those from CON group (p&lt;0.05). Specimens from some of these experimental groups presented greater nanomechanical properties (p&lt;0.05), and no morphological degradation at the resin-dentin interface after aging.</p><p>SIGNIFICANCE: The use of exogenous cross-linkers as dentin pre-treatment before bonding procedures may represent a suitable strategy to improve the longevity of universal adhesive systems applied to caries-affected dentin.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/b58241f4-5a33-4d74-90c9-165c60092275
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55305
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.36 (2020) nr.9 p.1151-1160
dc.subjectbiomaterials
dc.subjectbonding
dc.subjectcaries
dc.subjectnanoindentation
dc.subjectuniversal adhesives
dc.titleInfluence of flavonoids on long-term bonding stability on caries-affected dentineng
dc.typeArticleeng
dc.typeArtículospa
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