H<sub>2</sub>O<sub>2</sub> Concentration in Exhaled Breath Condensate Increases After Phonotrauma: A Promise of Noninvasive Monitoring?

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dc.coverageDOI: 10.1016/j.jvoice.2022.02.021
dc.creatorGuzmán, Marco
dc.creatorAraneda, Oscar F.
dc.creatorCastro, Christian
dc.creatorAcevedo, Karol
dc.creatorPacheco, Constanza
dc.creatorMorán, Camilo
dc.creatorQuezada, Camilo
dc.date2022
dc.date.accessioned2025-11-18T19:41:54Z
dc.date.available2025-11-18T19:41:54Z
dc.description<p>Purpose: The present study was designed to observe the concentration of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in exhaled breath condensate (EBC) after induced phonotrauma. Methods: Thirty-five participants were randomly assigned to one of two conditions (1) Vocal demand and (2) Control. Participants in the experimental group (vocal demand) were asked to read aloud some texts during 1 hour, at 85-90 dB. Inflammation (H<sub>2</sub>O<sub>2</sub> from exhaled breath condensate), acoustic, aerodynamic, and subjective measures were obtained at four time points: before vocal demand (baseline), immediately after baseline, 4-hour after baseline, and 24 hours after baseline. The same acquisition process was implemented for subjects in control group, except that they were not asked to engage in any vocal demand tasks at all. Results: As for biological samples, a significant effect for group was observed. Higher values were found for participants in experimental condition. Significant differences were observed for within contrasts in the experimental group, namely 4 hours against baseline, 4 hours against immediately post, and 24 hours against 4 hours. Instrumental outcomes did not show significant differences across the different conditions at any time points. Self-reported measures (vocal fatigue and sensation of muscle tension) showed a significant main effect for group and main effect for condition. Conclusions: Intense vocal demand causes an increase in the concentration of H<sub>2</sub>O<sub>2</sub> obtained from EBC at four hours after baseline, which is compatible with the generation of an inflammatory process in the vocal folds (phonotrauma). Moreover, the increase in the sensation of vocal fatigue and muscle tension after demand tasks seems to be an immediate reaction that did not match in time with the increment of H<sub>2</sub>O<sub>2</sub> concentration.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/74febaec-473b-4dd3-997f-4f8cb6d69b22
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/52064
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.38 (2022) nr.5 p.1186-1192
dc.subjectVocal folds inflammation
dc.subjectPhonotrauma
dc.subjectVocal demand
dc.subjectVocal fatigue
dc.subjectPhonatory effort
dc.titleH<sub>2</sub>O<sub>2</sub> Concentration in Exhaled Breath Condensate Increases After Phonotrauma: A Promise of Noninvasive Monitoring?eng
dc.typeArticleeng
dc.typeArtículospa
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