Leukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Disease

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dc.coverageDOI: 10.1159/000519003
dc.creatorRocha, Thiara Barcelos
dc.creatorGarate, Ana Lorena Sousa De Vasconcelos
dc.creatorBeraldo, Rodrigo Fedatto
dc.creatorLanças, Sean Hideo Shirata
dc.creatorLeite, Fábio Vicente
dc.creatorQuera, Rodrigo
dc.creatorBarros, Jaqueline Ribeiro
dc.creatorBaima, Julio Pinheiro
dc.creatorSaad-Hossne, Rogerio
dc.creatorSassaki, Ligia Yukie
dc.date2021
dc.date.accessioned2025-11-18T19:54:16Z
dc.date.available2025-11-18T19:54:16Z
dc.description<p>Cutaneous involvement is one of the most common extraintestinal manifestations of inflammatory bowel disease (IBD). More commonly, pyoderma gangrenosum and erythema nodosum are noted, but psoriasis, aphthous stomatitis, Sweet's syndrome, and vasculitis may also occur. Leukocytoclastic vasculitis (LCV) is a rare cutaneous manifestation, characterized by the appearance of palpable purpura, urticaria, and ulcer-necrotic lesions predominantly in the lower extremities that improve with immunosuppressive therapy. In this case, we report a patient with CD and LCV. We also searched the literature on the diagnosis and treatment of LCV in patients with CD. Female, 31, presented with diarrhea containing mucus and blood, abdominal pain, arthralgia, and enanthematous plaques and ulcers with a hematinic background in the lower extremities. The results of the colonoscopy were compatible with CD and skin biopsy showed signs of LCV. Systemic autoimmune disease and primary vasculitis were ruled out. The patient received treatment with a systemic corticosteroid and the skin lesions improved. Outpatient treatment with antitumor necrosis factor therapy was initiated to promote skin healing and IBD clinical remission. As LCV is a rare manifestation of IBD, it is necessary to distinguish this dermatopathy from other systemic vasculitis. The engagement of a multidisciplinary team is essential for the correct diagnosis and management.</p>eng
dc.descriptionCutaneous involvement is one of the most common extraintestinal manifestations of inflammatory bowel disease (IBD). More commonly, pyoderma gangrenosum and erythema nodosum are noted, but psoriasis, aphthous stomatitis, Sweet's syndrome, and vasculitis may also occur. Leukocytoclastic vasculitis (LCV) is a rare cutaneous manifestation, characterized by the appearance of palpable purpura, urticaria, and ulcer-necrotic lesions predominantly in the lower extremities that improve with immunosuppressive therapy. In this case, we report a patient with CD and LCV. We also searched the literature on the diagnosis and treatment of LCV in patients with CD. Female, 31, presented with diarrhea containing mucus and blood, abdominal pain, arthralgia, and enanthematous plaques and ulcers with a hematinic background in the lower extremities. The results of the colonoscopy were compatible with CD and skin biopsy showed signs of LCV. Systemic autoimmune disease and primary vasculitis were ruled out. The patient received treatment with a systemic corticosteroid and the skin lesions improved. Outpatient treatment with antitumor necrosis factor therapy was initiated to promote skin healing and IBD clinical remission. As LCV is a rare manifestation of IBD, it is necessary to distinguish this dermatopathy from other systemic vasculitis. The engagement of a multidisciplinary team is essential for the correct diagnosis and management. © 2021 The Author(s). Published by S. Karger AG, Basel.spa
dc.identifierhttps://investigadores.uandes.cl/en/publications/ea9ffff9-44fc-44a8-a0f4-ad93fe54e31e
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/58679
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.15 (2021) date: 2021-09-23 nr.3 p.825-831
dc.subjectCase report
dc.subjectCrohn s disease
dc.subjectExtraintestinal manifestation
dc.subjectInflammatory bowel disease
dc.subjectLeukocytoclastic vasculitis
dc.subjectSDG 3 - Good Health and Well-being
dc.titleLeukocytoclastic Vasculitis as an Extraintestinal Manifestation of Crohn's Diseaseeng
dc.typeArticleeng
dc.typeArtículospa
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