Body mass index and blood pressure in bipolar patients: Target cardiometabolic markers for clinical practice

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dc.coverageDOI: 10.1016/j.jad.2020.12.121
dc.creatorCuellar-Barboza, Alfredo B.
dc.creatorCabello-Arreola, Alejandra
dc.creatorWinham, Stacey J.
dc.creatorColby, Colin
dc.creatorRomo-Nava, Francisco
dc.creatorNunez, Nicolas A.
dc.creatorMorgan, Robert J.
dc.creatorGupta, Ruchi
dc.creatorBublitz, Joshua T.
dc.creatorPrieto, Miguel L.
dc.creatorDe Filippis, Elena A.
dc.creatorLopez-Jimenez, Francisco
dc.creatorMcElroy, Susan L.
dc.creatorBiernacka, Joanna M.
dc.creatorFrye, Mark A.
dc.creatorVeldic, Marin
dc.date2021
dc.date.accessioned2025-11-18T19:40:15Z
dc.date.available2025-11-18T19:40:15Z
dc.description<p>Objective: To evaluate the association between cardiometabolic markers and bipolar disorder (BD), examining the impact of sex and cardiometabolic medication use, from a large case-control biorepository of more than 1300 participants. Patients and Methods: Recruited from July 2009 through September 2017, cardiometabolic markers were harvested from electronic health records (EHR) of participants (n=661) from the Mayo Clinic Individualized Medicine Biobank for Bipolar Disorder and Mayo Clinic Biobank age-sex-matched controls (n=706). Markers were compared between cases and controls using logistic regression, stratified by sex, adjusting for cardiometabolic medications and current smoking status. We studied the effect of psychotropics in case-only analyses. Results: The mean age of the sample was 52.5 ± 11.6 years and 55% were female. BD patients had higher rates of smoking, but lower utilization of lipid-lowering medication compared with controls. After adjustment, BD was associated with obesity [Odds ratio (CI) 1.62 (1.22-2.15)], elevated systolic blood pressure (SBP) [2.18 (1.55-3.06)] and elevated triglycerides [1.58 (1.13-2.2)]. When stratified by sex, obesity [1.8 (1.23-2.66)] and systolic blood pressure [2.32 (1.46-3.7)] were associated with BD females compared to female controls; however, only systolic blood pressure [2.04 (1.23-3.42)] was associated with male bipolars compared to male controls. Psychotropics were marginally associated with mean BMI, abnormal triglycerides, and HbA1c. Limitations: EHR cross-sectional data Conclusion: To our knowledge, this is the largest case controlled study to date to explore the association between cardiometabolic markers and bipolar disorder adjusting for utilization of cardiometabolic medication. Identification of significant, non-laboratory based cardiometabolic markers that are associated with increased risk of major cardiovascular adverse events in patients with bipolar disorder, underscores, both the utility and importance of risk monitoring that can be easily done in community mental health centers.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/2840c769-bdcf-429a-a49b-6f6ade929900
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/51202
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.282 (2021) date: 2021-03-01 p.637-643
dc.subjectBipolar disorder
dc.subjectCardiometabolic markers
dc.subjectHigh blood pressure
dc.subjectObesity
dc.subjectTriglycerides
dc.subjectSDG 3 - Good Health and Well-being
dc.titleBody mass index and blood pressure in bipolar patients: Target cardiometabolic markers for clinical practiceeng
dc.typeArticleeng
dc.typeArtículospa
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