Efficient Hydroxyapatite Extraction from Salmon Bone Waste: An Improved Lab-Scaled Physico-Chemico-Biological Process

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dc.coverageDOI: 10.3390/molecules29174002
dc.creatorMuñoz, Francisco
dc.creatorGuerra, Ignacio
dc.creatorGarcia, Maria José
dc.creatorEnrione, Javier
dc.creatorOrtega, Nicole
dc.creatorHaidar, Ziyad S.
dc.date2024
dc.date.accessioned05-01-2026 18:15
dc.date.available05-01-2026 18:15
dc.description<p>The demand for novel tissue grafting and regenerative wound care biomaterials is growing as traditional options often fall short in biocompatibility, functional integration with human tissue, associated cost(s), and sustainability. Salmon aquaculture generates significant volumes of waste, offering a sustainable opportunity for biomaterial production, particularly in osteo-conduction/-induction, and de novo clinical/surgical bone regeneration. Henceforth, this study explores re-purposing salmon waste through a standardized pre-treatment process that minimizes the biological waste content, followed by a treatment stage to remove proteins, lipids, and other compounds, resulting in a mineral-rich substrate. Herein, we examined various methods—alkaline hydrolysis, calcination, and NaOH hydrolysis—to better identify and determine the most efficient and effective process for producing bio-functional nano-sized hydroxyapatite. Through comprehensive chemical, physical, and biological assessments, including Raman spectroscopy and X-ray diffraction, we also optimized the extraction process. Our modified and innovative alkaline hydrolysis–calcination method yielded salmon-derived hydroxyapatite with a highly crystalline structure, an optimal Ca/P ratio, and excellent biocompatibility. The attractive nano-scale cellular/tissular properties and favorable molecular characteristics, particularly well-suited for bone repair, are comparable to or even surpass those of synthetic, human, bovine, and porcine hydroxyapatite, positioning it as a promising candidate for use in tissue engineering, wound healing, and regenerative medicine indications.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/e3870521-d5c8-452b-8762-f28a75cb616b
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.29 (2024) nr.17 p.1-11
dc.subjectbiomaterial
dc.subjectbone repair
dc.subjecthydroxyapatite
dc.subjectosseoregenerate
dc.subjectprocess
dc.subjectsalmon bone
dc.subjectwaste
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEfficient Hydroxyapatite Extraction from Salmon Bone Waste: An Improved Lab-Scaled Physico-Chemico-Biological Processeng
dc.typeArticleeng
dc.typeArtículospa
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