Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: Multilocation analysis in 398 cities

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dc.coverageDOI: 10.1136/bmj.n534
dc.creatorMeng, Xia
dc.creatorLiu, Cong
dc.creatorChen, Renjie
dc.creatorSera, Francesco
dc.creatorVicedo-Cabrera, Ana Maria
dc.creatorMilojevic, Ai
dc.creatorGuo, Yuming
dc.creatorTong, Shilu
dc.creatorDe Sousa Zanotti Stagliorio Coelho, Micheline
dc.creatorSaldiva, Paulo Hilario Nascimento
dc.creatorLavigne, Eric
dc.creatorCorrea, Patricia Matus
dc.creatorOrtega, Nicolas Valdes
dc.creatorOsorio, Samuel
dc.creatorGarcia,
dc.creatorKyselý, Jan
dc.creatorUrban, Aleš
dc.creatorOrru, Hans
dc.creatorMaasikmets, Marek
dc.creatorJaakkola, Jouni J.K.
dc.creatorRyti, Niilo
dc.creatorHuber, Veronika
dc.creatorSchneider, Alexandra
dc.creatorKatsouyanni, Klea
dc.creatorAnalitis, Antonis
dc.creatorHashizume, Masahiro
dc.creatorHonda, Yasushi
dc.creatorNg, Chris Fook Sheng
dc.creatorNunes, Baltazar
dc.creatorTeixeira, João Paulo
dc.creatorHolobaca, Iulian Horia
dc.creatorFratianni, Simona
dc.creatorKim, Ho
dc.creatorTobias, Aurelio
dc.creatorÍñiguez, Carmen
dc.creatorForsberg, Bertil
dc.creatorÅström, Christofer
dc.creatorRagettli, Martina S.
dc.creatorGuo, Yue Liang Leon
dc.creatorPan, Shih Chun
dc.creatorLi, Shanshan
dc.creatorBell, Michelle L.
dc.creatorZanobetti, Antonella
dc.creatorSchwartz, Joel
dc.creatorWu, Tangchun
dc.creatorGasparrini, Antonio
dc.creatorKan, Haidong
dc.date2021
dc.date.accessioned2025-11-18T19:55:56Z
dc.date.available2025-11-18T19:55:56Z
dc.description<p>AbstractObjective To evaluate the short term associations between nitrogen dioxide (NO 2) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. Design Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. Setting 398 cities in 22 low to high income countries/regions. Main outcome measures Daily deaths from total (62.8 million), cardiovascular (19.7 million), and respiratory (5.5 million) causes between 1973 and 2018. Results On average, a 10 μg/m 3 increase in NO 2 concentration on lag 1 day (previous day) was associated with 0.46% (95% confidence interval 0.36% to 0.57%), 0.37% (0.22% to 0.51%), and 0.47% (0.21% to 0.72%) increases in total, cardiovascular, and respiratory mortality, respectively. These associations remained robust after adjusting for co-pollutants (particulate matter with aerodynamic diameter ≤10 μm or ≤2.5 μm (PM 10 and PM 2.5, respectively), ozone, sulfur dioxide, and carbon monoxide). The pooled concentration-response curves for all three causes were almost linear without discernible thresholds. The proportion of deaths attributable to NO 2 concentration above the counterfactual zero level was 1.23% (95% confidence interval 0.96% to 1.51%) across the 398 cities. Conclusions This multilocation study provides key evidence on the independent and linear associations between short term exposure to NO 2 and increased risk of total, cardiovascular, and respiratory mortality, suggesting that health benefits would be achieved by tightening the guidelines and regulatory limits of NO 2.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/7e5beeae-1d1c-4e26-8420-e80c491cc374
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/59516
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.372 (2021) date: 2021-03-24
dc.titleShort term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: Multilocation analysis in 398 citieseng
dc.typeArticleeng
dc.typeArtículospa
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