El complejo HDL-S1P de sangre de cordón circulante preserva la integridad de la vasculatura fetoplacentaria

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dc.coverageDOI: 10.1016/j.bbalip.2020.158632
dc.creatorDel Gaudio, Ilaria
dc.creatorSreckovic, Ivana
dc.creatorZardoya-Laguardia, Pablo
dc.creatorBernhart, Eva
dc.creatorChristoffersen, Christina
dc.creatorFrank, Saša
dc.creatorMarsche, Gunther
dc.creatorIllanes, Sebastian E.
dc.creatorWadsack, Christian
dc.date2020
dc.date.accessioned2025-11-18T19:47:35Z
dc.date.available2025-11-18T19:47:35Z
dc.description<p>Perinatal and long-term offspring morbidities are strongly dependent on the preservation of placental vascular homeostasis during pregnancy. In adults, the HDL-apoM-S1P complex protects the endothelium and maintains vascular integrity. However, the metabolism and biology of cord blood-derived HDLs (referred to as neonatal HDL, nHDL) strikingly differ from those in adults. Here, we investigate the role of neonatal HDLs in the regulation of placental vascular function. We show that nHDL is a major carrier of sphingosine-1-phosphate (S1P), which is anchored to the particle through apoM (r<sup>s</sup> = 0.90, p &lt; 0.0001) in the fetal circulation. Furthermore, this complex interacts with S1P receptors on the feto-placental endothelium and activates specifically extracellular signal-regulated protein kinases 1 and 2 (ERK) and phospholipase C (PLC) downstream signaling, promotes endothelial cell proliferation and calcium flux. Notably, the nHDL-S1P complex triggers actin filaments reorganization, leading to an enhancement of placental endothelial barrier function. Additionally, nHDL induces vasorelaxation of isolated placental chorionic arteries. Taken together, these results suggest that circulating nHDL exerts vasoprotective effects on the feto-placental endothelial barrier mainly via S1P signaling.</p>eng
dc.description<p class="MsoNormal">Perinatal and long-term offspring morbidities are strongly dependent on the preservation of placental vascular homeostasis during pregnancy. In adults, the HDL-apoM-S1P complex protects the endothelium and maintains vascular integrity. However, the metabolism and biology of cord blood-derived HDLs (referred to as neonatal HDL, nHDL) strikingly differ from those in adults. Here, we investigate the role of neonatal HDLs in the regulation of placental vascular function. We show that nHDL is a major carrier of sphingosine-1-phosphate (S1P), which is anchored to the particle through apoM (r<sup>s</sup> = 0.90, p &lt; 0.0001) in the fetal circulation. Furthermore, this complex interacts with S1P receptors on the feto-placental endothelium and activates specifically extracellular signal-regulated protein kinases 1 and 2 (ERK) and phospholipase C (PLC) downstream signaling, promotes endothelial cell proliferation and calcium flux. Notably, the nHDL-S1P complex triggers actin filaments reorganization, leading to an enhancement of placental endothelial barrier function. Additionally, nHDL induces vasorelaxation of isolated placental chorionic arteries. Taken together, these results suggest that circulating nHDL exerts vasoprotective effects on the feto-placental endothelial barrier mainly via S1P signaling.</p>spa
dc.identifierhttps://investigadores.uandes.cl/en/publications/39953b07-6630-48c8-a53a-e370bcce4513
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55111
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.1865 (2020) nr.4
dc.subjectBioactive lipids
dc.subjectHigh-density lipoprotein
dc.subjectHuman placenta
dc.subjectPlacental vascular endothelium
dc.subjectPregnancy
dc.subjectLípidos bioactivos
dc.subjectLipoproteína de alta densidad
dc.subjectPlacenta humana
dc.subjectEndotelio vascular placentario
dc.subjectEl embarazo
dc.titleEl complejo HDL-S1P de sangre de cordón circulante preserva la integridad de la vasculatura fetoplacentariaspa
dc.titleCirculating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculatureeng
dc.typeArticleeng
dc.typeArtículospa
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