The impact of gender and peripheral blood parameters on the characteristics of L-PRF membranes

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dc.coverageDOI: 10.1016/j.jobcr.2022.08.020
dc.creatorAldana, Catherine Andrade
dc.creatorAmenabar, Felipe Ugarte
dc.creatorSilva, Carolina Inostroza
dc.creatorCalderon, Paulo Diaz
dc.creatorMessina, David Rosenberg
dc.creatorCarrasco, Nelson Pinto
dc.creatorQuirynen, Marc
dc.date2022
dc.date.accessioned2025-11-18T19:42:09Z
dc.date.available2025-11-18T19:42:09Z
dc.description<p>Aim: The purpose of this study was to evaluate the impact of gender and peripheral blood parameters on the characteristics of Leucocyte-and Platelet-Rich Fibrin (L-PRF) membranes and to describe histologically three different zones of L-PRF membranes.</p><p>Methods: Blood was collected from twenty healthy donors (10 men and 10 women). Peripheral blood parameters including leucocyte and platelet counts, and fibrinogen levels were recorded. L-PRF membranes were prepared to quantify the release of growth factors (PDGF, VEGF, BMP-2, and BMP-9) at 1, 2, 3 and 7 days and for histological examination. Three zones within each L-PRF membrane (face, body, and tail) were analysed separately, quantifying the area of leucocytes, platelets, and fibrin in percentage. The Young's modulus of the membranes was also considered (during tensile and compression tests).</p><p>Results: Women had significantly higher fibrinogen levels in their peripheral blood, and a higher release of BMP-9, whereas men showed a significantly higher Young's modulus in compression tests. The histology revealed significant differences in cellular content and fibrin concentration between the 3 areas, with the face being biologically the richest.</p><p>Conclusion: Several factors influenced the final characteristics of L-PRF membranes. These need to be taken into consideration when interpreting the results of research, but especially in clinical practice.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/258e705b-f37a-4662-be85-d4a1545b9c53
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/52202
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.12 (2022) date: 2022-11-01 nr.6 p.753-759
dc.subjectFibrinogen
dc.subjectGrowth factors
dc.subjectHistology
dc.subjectL-PRF
dc.subjectLeucocytes
dc.subjectPlatelet concentrates
dc.subjectPlatelet rich fibrin
dc.titleThe impact of gender and peripheral blood parameters on the characteristics of L-PRF membraneseng
dc.typeArticleeng
dc.typeArtículospa
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