The Incorporation of Copper-Doped Bioactive Glass Nanoparticles into Resin Composites Improves Their Biological, Mechanical and Adhesive Properties

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dc.coverageDOI: 10.3290/j.jad.c_2014
dc.creatorAliaga-Gálvez, Romina
dc.creatorGutiérrez, Mario Felipe
dc.creatorValenzuela, Benjamín
dc.creatorGeraldeli, Saulo
dc.creatorAbuna, Gabriel
dc.creatorInostroza, Carolina
dc.creatorBravo, Cristian
dc.creatorCochinski, Gabriel
dc.creatorLoguercio, Alessandro D.
dc.date2025
dc.date.accessioned2025-11-18T19:51:01Z
dc.date.available2025-11-18T19:51:01Z
dc.description<p>Purpose: This study aims to develop and characterize copper-doped bioactive glass nanoparticles (BG/CuNp), and to evaluate the effects of their addition into a resin composite on antimicrobial activity (AMA), cytotoxicity (CTX), ultimate tensile strength (UTS), Knoop microhardness (KHN), as well as immediate resin-dentin microtensile bond strength (μTBS), nanoleakage (NL) and in-situ degree of conversion (DC). Materials and Methods: BG/CuNp were added to a resin composite at different concentrations (0% [control]; 5, 10 and 20 wt%). The AMA was evaluated against Streptococcus mutans. For CTX, the Gingival mesenchymal stem cells (GMSC) cell line was used. For UTS and KHN, specimens were tested after 24 h and 28 days. For bonding evaluation, a universal adhesive was applied on flat dentin surfaces, experimental resin composite build-ups were prepared, and specimens were sectioned to obtain resin–dentin sticks. These were evaluated for μTBS, NL and DC after water storage. Data were submitted to statistical analyses (α = 0.05). Results: The addition of 5% and 10% of BG/CuNp increases AMA (P &lt; 0.05), while the CTX remained unchanged with resin-containing BG/CuNp (P &gt; 0.05). UTS and KHN remained stable with the addition of 5% and 10% of BG/CuNp at 24 h, but showed significantly higher values compared to the control after 28 d (P &lt; 0.05). μTBS and in-situ DC remained unchanged with BG/CuNp addition, regardless of the concentration added. However, significantly lower NL was observed for BG/CuNp groups (P &lt; 0.05). Conclusion: The addition of BG/CuNp in the tested concentrations into a resin composite may be an alternative to provide antimicrobial activity and improve the integrity of the hybrid layer, without compromising biological, adhesives and mechanical properties.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/092ef500-3f4c-41ab-9d2a-a161daeef131
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/56920
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.27 (2025) p.103-114
dc.subjectbioactive glass
dc.subjectcopper
dc.subjectmicrotensile bond strength and nanoleakage
dc.subjectnanoparticles
dc.subjectresin composite
dc.titleThe Incorporation of Copper-Doped Bioactive Glass Nanoparticles into Resin Composites Improves Their Biological, Mechanical and Adhesive Propertieseng
dc.typeArticleeng
dc.typeArtículospa
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