New mesenchymal stem/stromal cell-based strategies for osteoarthritis treatment: targeting macrophage-mediated inflammation to restore joint homeostasis

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dc.coverageDOI: 10.1007/s00109-025-02547-8
dc.creatorAraya-Sapag, María Jesús
dc.creatorLara-Barba, Eliana
dc.creatorGarcía-Guerrero, Cynthia
dc.creatorHerrera-Luna, Yeimi
dc.creatorFlores-Elías, Yesenia
dc.creatorBustamante-Barrientos, Felipe A.
dc.creatorAlbornoz, Guillermo G.
dc.creatorContreras-Fuentes, Consuelo
dc.creatorYantén-Fuentes, Liliana
dc.creatorLuque-Campos, Noymar
dc.creatorVega-Letter, Ana María
dc.creatorToledo, Jorge
dc.creatorLuz-Crawford, Patricia
dc.date2025
dc.date.accessioned2025-11-18T19:44:20Z
dc.date.available2025-11-18T19:44:20Z
dc.description<p>Macrophages are pivotal in osteoarthritis (OA) pathogenesis, as their dysregulated polarization can contribute to chronic inflammatory processes. This review explores the molecular and metabolic mechanisms that influence macrophage polarization and identifies potential strategies for OA treatment. Currently, non-surgical treatments for OA focus only on symptom management, and their efficacy is limited; thus, mesenchymal stem/stromal cells (MSCs) have gained attention for their anti-inflammatory and immunomodulatory capabilities. Emerging evidence suggests that small extracellular vesicles (sEVs) derived from MSCs can modulate macrophage function, thus offering potential therapeutic benefits in OA. Additionally, the transfer of mitochondria from MSCs to macrophages has shown promise in enhancing mitochondrial functionality and steering macrophages toward an anti-inflammatory M2-like phenotype. While further research is needed to confirm these findings, MSC-based strategies, including the use of sEVs and mitochondrial transfer, hold great promise for the treatment of OA and other chronic inflammatory diseases.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/693f775b-f22d-4b89-aba8-2af28e14185e
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/53344
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.103 (2025) nr.6 p.651-669
dc.subjectHomeostasis
dc.subjectMacrophages
dc.subjectOsteoarthritis
dc.titleNew mesenchymal stem/stromal cell-based strategies for osteoarthritis treatment: targeting macrophage-mediated inflammation to restore joint homeostasiseng
dc.typeReview articleeng
dc.typeArtículo de revisiónspa
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