Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: A case control study

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dc.coverageDOI: 10.1111/jre.12008
dc.creatorChaparro, A.
dc.creatorSanz, A.
dc.creatorQuintero, A.
dc.creatorInostroza, C.
dc.creatorRamirez, V.
dc.creatorCarrion, F.
dc.creatorFigueroa, F.
dc.creatorSerra, R.
dc.creatorIllanes, S. E.
dc.date2013
dc.date.accessioned2025-11-18T19:47:35Z
dc.date.available2025-11-18T19:47:35Z
dc.description<p>Aim(s): To explore the relationship between biomarkers of systemic inflammation in plasma and gingival crevicular fluid in early pregnancy and the subsequent development of pre-eclampsia in patients with periodontitis. Materials and Methods: A case-control study was performed. From a cohort composed of 126 pregnant women, 43 normotensive healthy pregnant women were randomly selected, and 11 cases of preeclampsia were identified. Plasmatic and gingival crevicular fluid (GCF) samples were collected in early pregnancy (11-14 wk gestation). The levels of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) were measured in the plasma and GCF samples, whereas the level of C-reactive protein (CRP) was measured in plasma samples. Biomarkers were determined by ELISA assays. The data were analysed using descriptive statistics, and the association between variables was estimated through logistic regression models. Results: There was observed an association between pre-eclampsia and plasmatic levels of CRP (OR: 1.07; p = 0.003). Additionally, pre-eclampsia also was associated with IL-6 levels in GCF samples in early pregnancy (OR: 1.05; p = 0.039). A multiple logistic regression model suggests that increased levels of IL-6 in GCF (OR = 1.06; p = 0.02; CI 95% 1.007-1.117) in early pregnancy increase the risk of developing pre-eclampsia. Conclusion(s): Pregnant women with periodontitis who later development pre-eclampsia, shows increased levels of IL-6 in GCF and CRP in plasma during early pregnancy. Periodontal disease could contribute to systemic inflammation in early pregnancy via a local increase of IL-6 and the systemic elevation of CRP. Therefore, both inflammatory markers could be involved in the relationship between periodontal disease and pre-eclampsia.</p>eng
dc.descriptionAim(s)<br/>To explore the relationship between biomarkers of systemic inflammation in plasma and gingival crevicular fluid in early pregnancy and the subsequent development of pre-eclampsia in patients with periodontitis.<br/>Materials and Methods<br/>A case-control study was performed. From a cohort composed of 126 pregnant women, 43 normotensive healthy pregnant women were randomly selected, and 11 cases of preeclampsia were identified. Plasmatic and gingival crevicular fluid (GCF) samples were collected in early pregnancy (11–14 wk gestation). The levels of interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) were measured in the plasma and GCF samples, whereas the level of C-reactive protein (CRP) was measured in plasma samples. Biomarkers were determined by ELISA assays. The data were analysed using descriptive statistics, and the association between variables was estimated through logistic regression models.<br/>Results<br/>There was observed an association between pre-eclampsia and plasmatic levels of CRP (OR: 1.07; p = 0.003). Additionally, pre-eclampsia also was associated with IL-6 levels in GCF samples in early pregnancy (OR: 1.05; p = 0.039). A multiple logistic regression model suggests that increased levels of IL-6 in GCF (OR = 1.06; p = 0.02; CI 95% 1.007–1.117) in early pregnancy increase the risk of developing pre-eclampsia.<br/>Conclusion(s)<br/>Pregnant women with periodontitis who later development pre-eclampsia, shows increased levels of IL-6 in GCF and CRP in plasma during early pregnancy. Periodontal disease could contribute to systemic inflammation in early pregnancy via a local increase of IL-6 and the systemic elevation of CRP. Therefore, both inflammatory markers could be involved in the relationship between periodontal disease and pre-eclampsia.spa
dc.identifierhttps://investigadores.uandes.cl/en/publications/f2e78f0d-689e-47fe-97bc-49c45f369758
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55113
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.48 (2013) nr.3 p.302-307
dc.subjectC-reactive protein
dc.subjectInterleukin-6
dc.subjectPeriodontal disease
dc.subjectPre-eclampsia
dc.subjectPregnancy
dc.subjectSystemic inflammation
dc.titleIncreased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: A case control studyeng
dc.typeArticleeng
dc.typeArtículospa
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