Plasmacytoma and plasma cell myeloma affecting the jaws: A multi-institutional collaborative study

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dc.coverageDOI: 10.1111/jop.13213
dc.creatorSouza, Lucas Lacerda de
dc.creatorCáceres, Cinthia Verónica Bardález López de
dc.creatorVargas, Pablo Agustin
dc.creatorLopes, Márcio Ajudarte
dc.creatorSantos-Silva, Alan Roger
dc.creatorSilva, Wagner Gomes da
dc.creatorPrado-Ribeiro, Ana Carolina
dc.creatorBrandão, Thais Bianca
dc.creatorPereira, Juliana
dc.creatorMesquita, Ricardo Alves
dc.creatorPontes, Flávia Sirotheau Correa
dc.creatorGonzález-Arriagada, Wilfredo Alejandro
dc.creatorPedraza, Ricardo Martinez
dc.creatorAndrade, Bruno Augusto Benevenuto de
dc.creatorRomañach, Mario José
dc.creatorSoares, Ciro Dantas
dc.creatorCarvalho, Maria Goretti Freire de
dc.creatorPires, Fabio Ramôa
dc.creatorCarlos, Roman
dc.creatorFonseca, Felipe Paiva
dc.creatorPontes, Hélder Antônio Rebelo
dc.creatorde Almeida, Oslei Paes
dc.date2021
dc.date.accessioned2025-11-18T19:54:07Z
dc.date.available2025-11-18T19:54:07Z
dc.description<p>BACKGROUND: Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. They can manifest as a single lesion (plasmacytoma) or as multiple lesions (multiple myeloma).</p><p>METHODS: Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed and follow-up status were retrieved from the pathology reports.</p><p>RESULTS: Fifty-two cases were retrieved (mean age: 59.4 years) without sex predilection. The mandible was the most affected site (67.3%), usually associated with pain and/or paresthesia (53.8%). Lesions in other bones besides the jaws were reported for 24 patients (46.2%). Radiographically, tumours usually presented as poorly defined osteolytic lesions with unilocular or multilocular images, while microscopy revealed diffuse proliferation of neoplastic plasma cells with nuclear displacement and abundant eosinophilic cytoplasm. Two cases were classified as anaplastic, and amyloid deposits were found in two other cases. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, and monoclonality for kappa light chain predominated. The overall survival rate after 5 years of follow-up was 26.6%.</p><p>CONCLUSION: Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/33d3c2df-d5b8-49ed-89c1-ac7e4a8c6c10
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/58597
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.50 (2021) nr.6 p.613-621
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectJaw/diagnostic imaging
dc.subjectMiddle Aged
dc.subjectMultiple Myeloma/diagnostic imaging
dc.subjectNeoplasms, Plasma Cell/diagnostic imaging
dc.subjectPlasmacytoma/diagnostic imaging
dc.titlePlasmacytoma and plasma cell myeloma affecting the jaws: A multi-institutional collaborative studyeng
dc.typeArticleeng
dc.typeArtículospa
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