Reduced neutralization against Delta, Gamma, Mu, and Omicron BA.1 variants of SARS-CoV-2 from previous non-Omicron infection

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dc.coverageDOI: 10.1007/s00430-022-00753-6
dc.creatorPidal, Paola
dc.creatorFernández, Jorge
dc.creatorAirola, Constanza
dc.creatorAraujo, Miguel
dc.creatorMenjiba, Ana María
dc.creatorMartín, Héctor San
dc.creatorBruneau, Nicole
dc.creatorBalanda, Monserrat
dc.creatorElgueta, Coral
dc.creatorFasce, Rodrigo
dc.creatorValenzuela, María Teresa
dc.creatorOrellana, Ariel
dc.creatorRamírez, Eugenio
dc.date2022
dc.date.accessioned2025-11-18T19:48:53Z
dc.date.available2025-11-18T19:48:53Z
dc.description<p>The understanding of the host immune response to SARS-CoV-2 variants of concern is critical for improving diagnostics, therapy development, and vaccines. Here, we analyzed the level of neutralizing antibodies against SARS-CoV-2 D614G, Delta, Gamma, Mu, and Omicron variants in D614G infected healthcare workers during a follow-up up to 6 months after recovery. We followed up 76 patients: 60.5% were women and 39.5% men. The 96.1% and 3.9% were symptomatic and asymptomatic, respectively. The most frequent symptoms were headache, myalgia, and cough. The 65.8%, 65.8%, and 92.1% of the infected individuals were positive for neutralizing antibodies against D614G variant at 2, 4, and 6 months of follow-up, respectively. The 26.3%, 48.7% and 65.8% of patients neutralized Delta variant, 19.7%, 32.9% and 52.6% of patients neutralized Gamma, 7.9%, 19.7% and 44.7% of patients neutralized Mu, and 4.0%, 9.2% and 15.8% of patients neutralized Omicron. Low neutralization against Gamma and Mu variants was observed during the follow-up, and very low against the Omicron variant was detected during the same period. The median of neutralizing antibody titers against D614G and Delta variants increased significantly during the follow-up. An association was observed between the levels of neutralizing antibodies against D614G and Delta variants and the severity of the disease. Our results suggest an immune escape from neutralizing antibodies with the Omicron variant because of the many mutations localized in the S protein.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/27bf75ac-811a-4080-bf54-f919ce988a94
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/55803
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.212 (2022) nr.1 p.1-10
dc.subjectDelta variant
dc.subjectFollow-up immune response
dc.subjectGamma variant
dc.subjectMu variant
dc.subjectNeutralizing antibodies
dc.subjectOmicron SARS-CoV-2 variant
dc.subjectSDG 3 - Good Health and Well-being
dc.titleReduced neutralization against Delta, Gamma, Mu, and Omicron BA.1 variants of SARS-CoV-2 from previous non-Omicron infectioneng
dc.typeArticleeng
dc.typeArtículospa
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