Is bariatric surgery improving mitochondrial function in the renal cells of patients with obesity-induced kidney disease?

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dc.coverageDOI: 10.1016/j.phrs.2022.106488
dc.creatorCañizares, Stalin
dc.creatorGuaillas, Auki
dc.creatorVelarde, Francesca
dc.creatorde Vaca, Verónica Cabeza
dc.creatorTerán, Fuad
dc.creatorCaicedo, Andrés
dc.date2022
dc.date.accessioned2025-11-18T19:52:27Z
dc.date.available2025-11-18T19:52:27Z
dc.description<p>The role of mitochondria in health and disease has dramatically changed in the last decade. Its complex integration into cell physiology is comprised of key metabolic functions of great importance in health maintenance. Treating obesity seems to improve overall mitochondria tissue malfunction; however, the extent of their impact on patients remains elusive due to the lack of follow-up studies. It has been observed that procedures such as bariatric surgery (BS) can modify how our body absorbs nutrients, influencing metabolic processes and mitochondrial function in several cells and tissues. In fact, tissue analysis performed in vivo and in patients support that BS mitigates mitochondrial dysfunction in obese subjects. BS has been observed to reduce the presence of comorbidities such as type 2 diabetes (T2D) and hypertension (HTN) in patients. It is still unclear how BS specifically affects mitochondrial dynamics in obesity-induced comorbidities such as kidney disease. This article provides insightful information regarding the amelioration of mitochondrial dynamics in renal cells and systems after BS. Understanding the multiple pathways that lead to mitochondrial dysregulation in obesity-related kidney disease and relating them to the positive molecular changes after BS may lead to the development of adjuvant therapies to control this and other conditions with similar pathophysiological backgrounds.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/1fc664db-f32b-4f29-b3b6-8581fa4449cd
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/57720
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.185 (2022)
dc.subjectBariatric surgery
dc.subjectChronic kidney disease
dc.subjectMitochondria
dc.subjectMitochondrial function
dc.subjectObesity-induced kidney disease
dc.subjectRenal cells
dc.subjectSDG 3 - Good Health and Well-being
dc.titleIs bariatric surgery improving mitochondrial function in the renal cells of patients with obesity-induced kidney disease?eng
dc.typeReview articleeng
dc.typeArtículo de revisiónspa
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