Associations of diabesity with all-cause and cardiovascular disease mortality: Findings from the Mexico City Prospective Study

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dc.coverageDOI: 10.1111/dom.15528
dc.creatorPetermann-Rocha, Fanny
dc.creatorApolinar, Evelia
dc.creatorNazar, Gabriela
dc.creatorDiaz-Toro, Felipe
dc.creatorCelis, Andrés
dc.creatorDeo, Salil
dc.creatorFerrari, Gerson
dc.creatorO'Donovan, Gary
dc.date2024
dc.date.accessioned2025-11-18T19:55:23Z
dc.date.available2025-11-18T19:55:23Z
dc.description<p>Aim: To investigate the joint associations of diabetes and obesity with all-cause and cardiovascular disease (CVD) mortality in the Mexico City Prospective Study. Materials and Methods: In total, 154 128 participants (67.2% women) were included in this prospective analysis. Diabetes was self-reported, while body mass index was used to calculate obesity. Using diabetes and obesity classifications, six groups were created: (a) normal (no diabetes and normal weight); (b) normal weight and diabetes; (c) overweight but not diabetes (overweight); (d) overweight and diabetes (prediabesity); (e) obesity but not diabetes (obesity); and (f) obesity and diabetes (diabesity). Associations between these categories and outcomes were investigated using Cox proportional hazard models adjusted for confounder factors. Results: During 18.3 years of follow-up, 27 197 (17.6%) participants died (28.5% because of CV causes). In the maximally adjusted model, participants those with the highest risk {hazard ratio (HR): 2.37 [95% confidence interval (CI): 2.24-2.51]}, followed by those with diabesity [HR: 2.04 (95% CI: 1.94-2.15)]. Similar trends of associations were observed for CVD mortality. The highest CV mortality risk was observed in individuals with diabesity [HR: 1.80 (95% CI: 1.63-1.99)], followed by normal weight and diabetic individuals [HR: 1.78 (95% CI: 1.60-1.98)]. Conclusion: This large prospective study identified that diabetes was the main driver of all-cause and CVD mortality in all the categories studied, with diabesity being the riskiest. Given the high prevalence of both conditions in Mexico, our results reinforce the importance of initiating prevention strategies from an early age.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/37ce4bca-0277-4b14-af8a-0582890b81c3
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/59228
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.26 (2024) nr.6 p.2199-2208
dc.subjectdiabetes
dc.subjectmortality
dc.subjectobesity, cardiovascular diseases
dc.subjectBody Mass Index
dc.subjectCardiovascular Diseases/mortality
dc.subjectDiabetes Mellitus/epidemiology
dc.subjectProspective Studies
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectRisk Factors
dc.subjectProportional Hazards Models
dc.subjectMale
dc.subjectMexico/epidemiology
dc.subjectCause of Death
dc.subjectOverweight/mortality
dc.subjectObesity/complications
dc.subjectFemale
dc.subjectAdult
dc.subjectAged
dc.subjectPrediabetic State/mortality
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAssociations of diabesity with all-cause and cardiovascular disease mortality: Findings from the Mexico City Prospective Studyeng
dc.typeArticleeng
dc.typeArtículospa
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