Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Cases

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dc.coverageDOI: 10.1016/j.joen.2024.02.012
dc.creatorBrizuela, Claudia
dc.creatorMeza, Gastón
dc.creatorKhoury, Maroun
dc.date2024
dc.date.accessioned05-01-2026 18:05
dc.date.available05-01-2026 18:05
dc.description<p>Introduction: Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth. Methods: Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis. Results: After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization. Conclusions: This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/9728839b-a331-4fa7-919b-0370065d6132
dc.languageeng
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourcevol.50 (2024) nr.5 p.596-601
dc.subjectApical periodontitis
dc.subjectmature teeth
dc.subjectmesenchymal stem cell transplantation
dc.subjectplatelet-poor plasma
dc.subjectregenerative medicine
dc.titleRevolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Caseseng
dc.typeArticleeng
dc.typeArtículospa
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