Clinical and Genetic Correlates of Bipolar Disorder With Childhood-Onset Attention Deficit Disorder

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dc.coverageDOI: 10.3389/fpsyt.2022.884217
dc.creatorNunez, Nicolas A.
dc.creatorCoombes, Brandon J.
dc.creatorRomo-Nava, Francisco
dc.creatorBond, David J.
dc.creatorVande Voort, Jennifer
dc.creatorCroarkin, Paul E.
dc.creatorLeibman, Nicole
dc.creatorGardea Resendez, Manuel
dc.creatorVeldic, Marin
dc.creatorBetcher, Hannah
dc.creatorSingh, Balwinder
dc.creatorColby, Colin
dc.creatorCuellar-Barboza, Alfredo
dc.creatorPrieto, Miguel
dc.creatorMoore, Katherine M.
dc.creatorOzerdem, Aysegul
dc.creatorMcElroy, Susan L.
dc.creatorFrye, Mark A.
dc.creatorBiernacka, Joanna M.
dc.date2022
dc.date.accessioned2025-11-18T19:41:56Z
dc.date.available2025-11-18T19:41:56Z
dc.description<p>Background: Bipolar disorder (BD) with co-occurring attention deficit-hyperactivity disorder (ADHD) is associated with an unfavorable course of illness. We aimed to identify potential clinical and genetic correlates of BD with and without ADHD. Methods: Among patients with BD (N = 2,198) enrolled in the Mayo Clinic Bipolar Biobank we identified those with ADHD diagnosed in childhood (BD+cADHD; N = 350), those with adult-onset attention deficit symptoms (BD+aAD; N = 254), and those without ADHD (N = 1,594). We compared the groups using linear or logistic regression adjusting for age, sex, and recruitment site. For genotyped patients (N = 1,443), logistic regression was used to compare ADHD and BD polygenic risk scores (PRSs) between the BD groups, as well as to non-BD controls (N = 777). Results: Compared to the non-ADHD BD group, BD+cADHD patients were younger, more often men and had a greater number of co-occurring anxiety and substance use disorders (all p &lt; 0.001). Additionally, BD+cADHD patients had poorer responses to lithium and lamotrigine (p = 0.005 and p = 0.007, respectively). In PRS analyses, all BD patient subsets had greater genetic risk for BD and ADHD when compared to non-BD controls (p &lt; 0.001 in all comparisons). BD+cADHD patients had a higher ADHD-PRS than non-ADHD BD patients (p = 0.012). However, BD+aAD patients showed no evidence of higher ADHD-PRS than non-ADHD BD patients (p = 0.38). Conclusions: BD+cADHD was associated with a greater number of comorbidities and reduced response to mood stabilizing treatments. The higher ADHD PRS for the BD+cADHD group may reflect a greater influence of genetic factors on early presentation of ADHD symptoms.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/f653a287-9d51-4603-8446-2a8335597973
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/52086
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.13 (2022) date: 2022-04-14 p.884217
dc.subjectADHD
dc.subjectbipolar disorder
dc.subjectclinical features
dc.subjectgenetic
dc.subjectpolygenic risk score
dc.subjectSDG 3 - Good Health and Well-being
dc.titleClinical and Genetic Correlates of Bipolar Disorder With Childhood-Onset Attention Deficit Disordereng
dc.typeArticleeng
dc.typeArtículospa
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