Mitochondrial dysfunction in neurodegenerative disorders: Potential therapeutic application of mitochondrial transfer to central nervous system-residing cells

Simple item page
dc.coverageDOI: 10.1186/s12967-023-04493-w
dc.creatorBustamante-Barrientos, Felipe A.
dc.creatorLuque-Campos, Noymar
dc.creatorAraya, María Jesús
dc.creatorLara-Barba, Eliana
dc.creatorde Solminihac, Javiera
dc.creatorPradenas, Carolina
dc.creatorMolina, Luis
dc.creatorHerrera-Luna, Yeimi
dc.creatorUtreras-Mendoza, Yildy
dc.creatorElizondo-Vega, Roberto
dc.creatorVega-Letter, Ana María
dc.creatorLuz-Crawford, Patricia
dc.date2023
dc.date.accessioned2025-11-18T19:42:47Z
dc.date.available2025-11-18T19:42:47Z
dc.description<p>Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse neurodegenerative diseases. Current in vitro and in vivo approaches support that mitochondrial dysfunction is branded by several molecular and cellular defects, whose impact at different levels including the calcium and iron homeostasis, energetic balance and/or oxidative stress, makes it difficult to resolve them collectively given their multifactorial nature. Mitochondrial transfer offers an overall solution since it contains the replacement of damage mitochondria by healthy units. Therefore, this review provides an introducing view on the structure and energy-related functions of mitochondria as well as their dynamics. In turn, we summarize current knowledge on how these features are deregulated in different neurodegenerative diseases, including frontotemporal dementia, multiple sclerosis, amyotrophic lateral sclerosis, Friedreich ataxia, Alzheimer´s disease, Parkinson´s disease, and Huntington’s disease. Finally, we analyzed current advances in mitochondrial transfer between diverse cell types that actively participate in neurodegenerative processes, and how they might be projected toward developing novel therapeutic strategies.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/7b0e3295-b783-4505-adbb-4eced7c109fa
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/52520
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.21 (2023) nr.1
dc.titleMitochondrial dysfunction in neurodegenerative disorders: Potential therapeutic application of mitochondrial transfer to central nervous system-residing cellseng
dc.typeReview articleeng
dc.typeArtículo de revisiónspa
Files
Collections
PURE