NanoBubble-Mediated Oxygenation: elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies

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dc.coverageDOI: 10.20944/preprints202310.0962.v1
dc.creatorViafara Garcia, Sergio M.
dc.creatorKhan, Muhammad Saad
dc.creatorHaidar, Ziyad S.
dc.creatorAcevedo Cox, Juan Pablo
dc.date2023
dc.date.accessioned2025-11-18T19:43:11Z
dc.date.available2025-11-18T19:43:11Z
dc.description<p>Worldwide, hypoxia-related conditions, including cancer, COVID-19, and neuro-degenerative diseases, often lead to multi-organ failure and significant mortality. Oxygen, crucial for cellular function, becomes scarce as levels drop below 10 mmHg (&lt;2% O 2), triggering mitochondrial dysregulation and activating hypoxia-induced factors (HiFs). Herein, oxygen nanobubbles (OnB), an emerging versatile oxygen delivery platform, offer a novel approach to address hypoxia-related pathologies. This review explores OnB oxygen delivery strategies and systems, including diffusion, ultrasound, photodynamic, and pH-responsive nanobubbles. It delves into the nanoscale mechanisms of OnB, elucidating their role in mitochondrial metabolism (TFAM, PGC1alpha), hypoxic responses (HiF-1alpha), and their interplay in chronic pathologies including cancer and neurodegenerative disorders, amongst others. By understanding these dynamics and underlying mechanisms, this article aims to contribute to our accruing knowledge of OnB and the developing potential in ameliorating hypoxia- and metabolic stress-related conditions and fostering innovative therapies. </p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/65715c26-f708-4be2-84e7-1917cba509e5
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/52736
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.13 (2023) date: 2023-11-30 nr.23 p.1-30
dc.subjectcancer
dc.subjectdrug delivery
dc.subjecthypoxia
dc.subjectinnovation
dc.subjectmetabolism
dc.subjectmitochondria
dc.subjectmolecular
dc.subjectnanobubbles
dc.subjectoxygen
dc.subjectstress
dc.subjectSDG 3 - Good Health and Well-being
dc.titleNanoBubble-Mediated Oxygenation: elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologieseng
dc.typeReview articleeng
dc.typeArtículo de revisiónspa
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