MMP-9 Levels in the Gingival Crevicular Fluid of Chilean Rosacea Patients

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dc.coverageDOI: 10.3390/ijms23179858
dc.creatorFernández, Javier
dc.creatorJiménez, Constanza
dc.creatorBenadof, Dafna
dc.creatorMorales, Paulina
dc.creatorAstorga, Jessica
dc.creatorCáceres, Felipe
dc.creatorHernández, Marcela
dc.creatorFernández, Alejandra
dc.creatorValenzuela, Fernando
dc.date2022
dc.date.accessioned2025-11-18T19:54:39Z
dc.date.available2025-11-18T19:54:39Z
dc.description<p>Rosacea is a chronic inflammatory skin disease whose prevalence rates remain unknown in Chile. Laboratory benchmark testing for this disease is not useful, therefore, we aimed to evaluate the gingival crevicular fluid (GCF) levels of extracellular metalloproteinases (MMP)-2 and MMP-9 as novel rosacea biomarkers. We designed a cross-sectional study with a control group. Participants were systemically healthy adults (n = 20) and persons with rosacea (n = 18). We performed a periodontal evaluation and collected gingival crevicular fluid to measure MMP-2 and MMP-9 levels. Analysis showed mean and standard deviation of MMP-9 concentrations in the GCF for patients with rosacea was 764.52 ± 569.83 pg/mL; for healthy patients, it was 260.69 ± 170.43 pg/mL (p &lt; 0.05). The diagnosis of rosacea was responsible for the levels of MMP-9 in the GCF (p &lt; 0.05), as opposed to periodontitis, smoking, and age (p &gt; 0.05). The Area under ROC for MMP-9 was 0.869 (95%, C.I: 0.719–0.956), with a sensitivity of 72.22% and specificity of 81.58% for the diagnosis of rosacea. We conclude that the quantification of MMP-9 in the GCF could be used as a biomarker of rosacea. Also, rosacea was responsible for increasing the levels of MMP-9 in the GCF independent of periodontal status.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/0d2a9134-1fdc-407c-862d-b7cd59621f6e
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/58872
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.23 (2022) nr.17
dc.subjectbiomarkers
dc.subjectgingival crevicular fluid
dc.subjectrosacea
dc.subjectGingival Crevicular Fluid
dc.subjectCross-Sectional Studies
dc.subjectBiomarkers/analysis
dc.subjectHumans
dc.subjectRosacea/diagnosis
dc.subjectAdult
dc.subjectChile
dc.subjectMatrix Metalloproteinase 9
dc.titleMMP-9 Levels in the Gingival Crevicular Fluid of Chilean Rosacea Patientseng
dc.typeArticleeng
dc.typeArtículospa
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