Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and -9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus

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dc.coverageDOI: 10.1002/JPER.19-0743
dc.creatorChaparro, Alejandra
dc.creatorRealini, Ornella
dc.creatorHernández, Marcela
dc.creatorAlbers, Daniela
dc.creatorWeber, Laura
dc.creatorRamírez, Valeria
dc.creatorParam, Fernanda
dc.creatorKusanovic, Juan Pedro
dc.creatorSorsa, Timo
dc.creatorRice, Gregory Edward
dc.creatorIllanes, Sebastián E.
dc.date2021
dc.date.accessioned2025-11-18T19:41:02Z
dc.date.available2025-11-18T19:41:02Z
dc.description<p>Background: Gestational diabetes mellitus (GDM) is increasing worldwide and women with a history of GDM are at risk of developing type 2 diabetes which is a risk factor for periodontitis. The aim of this study was to explore the association between the concentrations of matrix metalloproteinase (MMP)-8 and -9 in gingival crevicular fluid (GCF) during early pregnancy with the periodontal diagnosis and the risk of GDM development. Methods: A prospective cohort study, including 314 women, enrolled at 11 to 14 weeks of pregnancy was conducted. A complete maternal/obstetric and periodontal exam was performed, and GCF samples were obtained for the MMP-8 and -9 determination by Multiplex Elisa Assays. Mann-Whitney test; Spearman's correlation and log-binomial regression model estimated the association between MMPs concentration in GCF and GDM. Results: Fourteen percent of the pregnancies were diagnosed with GDM. An increase in the concentration of MMP-8 and -9 in women with periodontitis stage III and IV compared to periodontitis stage I was observed (99.31 ng/mL [IQR: 85.32] versus 71.95 ng/mL [IQR: 54.04], and 262.4 ng/mL [IQR: 312.55] versus 114.1 ng/mL [IQR: 184.94], respectively). Women who developed GDM showed increased concentrations of MMP-8 and -9 in GCF since the beginning of pregnancy (P = 0.0381; P = 0.0302, respectively). MMP-8 concentration in GCF was associated with GDM (RR: 1.19; P = 0.045; CI 95% 1.00 to 1.40; and RR: 1.20; P = 0.063; CI 95% 0.99 to 1.45 in the adjusted model). Conclusion(s): GCF concentrations of MMP-8 and -9 at early of pregnancy are increased in women with severe periodontitis and associated with the GDM development.</p>eng
dc.identifierhttps://investigadores.uandes.cl/en/publications/9851feb2-b6be-47b0-9739-00372e7238da
dc.identifier.urihttps://repositorio.uandes.cl/handle/uandes/51605
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourcevol.92 (2021) date: 2021-02-01 nr.2 p.205-215
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDiabetes, Gestational
dc.subjectFemale
dc.subjectGingival Crevicular Fluid
dc.subjectHumans
dc.subjectMatrix Metalloproteinase 8
dc.subjectPeriodontitis/complications
dc.subjectPregnancy
dc.subjectProspective Studies
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEarly pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and -9 are associated with the severity of periodontitis and the development of gestational diabetes mellituseng
dc.typeArticleeng
dc.typeArtículospa
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