Browsing by Author "Wyneken, Úrsula"
Now showing 1 - 20 of 20
Results Per Page
Sort Options
Item Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?Luarte, Alejandro; Nardocci, Gino; Chakraborty, Ankush; Batiz, Luis Federico; Pino-Lagos, Karina; Wyneken, ÚrsulaItem Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?Luarte, Alejandro; Nardocci, Gino; Chakraborty, Ankush; Batiz, Luis Federico; Pino-Lagos, Karina; Wyneken, ÚrsulaItem Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?Luarte, Alejandro; Nardocci, Gino; Chakraborty, Ankush; Batiz, Luis Federico; Pino-Lagos, Karina; Wyneken, ÚrsulaItem eNOS-dependent S-nitrosylation of the NF-κB subunit p65 has neuroprotective effectsCaviedes, Ariel; Maturana, Barbara; Corvalán, Katherina; Engler, Alexander; Gordillo, Felipe; Varas-Godoy, Manuel; Smalla, Karl Heinz; Batiz, Luis Federico; Lafourcade, Carlos; Kaehne, Thilo; Wyneken, ÚrsulaItem eNOS-dependent S-nitrosylation of the NF-κB subunit p65 has neuroprotective effectsCaviedes, Ariel; Maturana, Barbara; Corvalán, Katherina; Engler, Alexander; Gordillo, Felipe; Varas-Godoy, Manuel; Smalla, Karl Heinz; Batiz, Luis Federico; Lafourcade, Carlos; Kaehne, Thilo; Wyneken, ÚrsulaItem eNOS-dependent S-nitrosylation of the NF-κB subunit p65 has neuroprotective effectsCaviedes, Ariel; Maturana, Barbara; Corvalán, Katherina; Engler, Alexander; Gordillo, Felipe; Varas-Godoy, Manuel; Smalla, Karl Heinz; Batiz, Luis Federico; Lafourcade, Carlos; Kaehne, Thilo; Wyneken, ÚrsulaItem Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus(Biological Research, 2024-12) Sánchez Rubio, Mario; Abarzúa Catalán, Lorena; Del Valle, Ana; Méndez Ruette, Maxs; Salazar, Natalia; Sigala, Jacinta; Sandoval, Soledad; Luarte, Alejandro; Monteiro, Lara J.; Wyneken, Úrsula; Illanes, Sebastián E.; Bátiz, Luis FedericoBackground: Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting consequences for the offspring. These effects show a sex bias. The mechanisms whereby prenatal stress induces functional and/or structural changes in the placental-fetal unit remain poorly understood. Maternal circulating small extracellular vesicles (sEVs) are good candidates to act as “stress signals” in mother-to-fetus communication. Using a repetitive restraint-based rat model of prenatal stress, we examined circulating maternal sEVs under stress conditions and tested whether they could target placental-fetal tissues. Results: Our mild chronic maternal stress during pregnancy paradigm induced anhedonic-like behavior in pregnant dams and led to intrauterine growth restriction (IUGR), particularly in male fetuses and placentas. The concentration and cargo of maternal circulating sEVs changed under stress conditions. Specifically, there was a significant reduction in neuron-enriched proteins and a significant increase in astrocyte-enriched proteins in blood-borne sEVs from stressed dams. To study the effect of repetitive restraint stress on the biodistribution of maternal circulating sEVs in the fetoplacental unit, sEVs from pregnant dams exposed to stress or control protocol were labeled with DiR fluorescent die and injected into pregnant females previously exposed to control or stress protocol. Remarkably, maternal circulating sEVs target placental/fetal tissues and, under stress conditions, fetal tissues are more receptive to sEVs. Conclusion: Our results suggest that maternal circulating sEVs can act as novel mediators/modulators of mother-to-fetus stress communication. Further studies are needed to identify placental/fetal cellular targets of maternal sEVs and characterize their contribution to stress-induced sex-specific placental and fetal changes.Item Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetusSánchez-Rubio, Mario; Abarzúa-Catalán, Lorena; del Valle, Ana; Méndez-Ruette, Maxs; Salazar, Natalia; Sigala, Jacinta; Sandoval, Soledad; Godoy, María Inés; Luarte, Alejandro; Monteiro, Lara J.; Romero, Roberto; Choolani, Mahesh A.; Wyneken, Úrsula; Illanes, Sebastián E.; Bátiz, Luis FedericoItem Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetusSánchez-Rubio, Mario; Abarzúa-Catalán, Lorena; del Valle, Ana; Méndez-Ruette, Maxs; Salazar, Natalia; Sigala, Jacinta; Sandoval, Soledad; Godoy, María Inés; Luarte, Alejandro; Monteiro, Lara J.; Romero, Roberto; Choolani, Mahesh A.; Wyneken, Úrsula; Illanes, Sebastián E.; Bátiz, Luis FedericoItem Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetusSánchez-Rubio, Mario; Abarzúa-Catalán, Lorena; del Valle, Ana; Méndez-Ruette, Maxs; Salazar, Natalia; Sigala, Jacinta; Sandoval, Soledad; Godoy, María Inés; Luarte, Alejandro; Monteiro, Lara J.; Romero, Roberto; Choolani, Mahesh A.; Wyneken, Úrsula; Illanes, Sebastián E.; Bátiz, Luis FedericoItem Methadone directly impairs central nervous system cells in vitroDe Gregorio, Cristian; Gallardo, Javiera; Berríos-Cárcamo, Pablo; Handy, Álex; Santapau, Daniela; González-Madrid, Antonia; Ezquer, Marcelo; Morales, Paola; Luarte, Alejandro; Corvalán, Daniela; Wyneken, Úrsula; Ezquer, FernandoItem Methadone directly impairs central nervous system cells in vitroDe Gregorio, Cristian; Gallardo, Javiera; Berríos-Cárcamo, Pablo; Handy, Álex; Santapau, Daniela; González-Madrid, Antonia; Ezquer, Marcelo; Morales, Paola; Luarte, Alejandro; Corvalán, Daniela; Wyneken, Úrsula; Ezquer, FernandoItem Methadone directly impairs central nervous system cells in vitroDe Gregorio, Cristian; Gallardo, Javiera; Berríos-Cárcamo, Pablo; Handy, Álex; Santapau, Daniela; González-Madrid, Antonia; Ezquer, Marcelo; Morales, Paola; Luarte, Alejandro; Corvalán, Daniela; Wyneken, Úrsula; Ezquer, FernandoItem Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEGEspinoza, Sofía; Arredondo, Sebastián B.; Barake, Francisca; Carvajal, Francisco; Guerrero, Fernanda G.; Segovia-Miranda, Fabian; Valenzuela, David M.; Wyneken, Úrsula; Rojas-Fernández, Alejandro; Cerpa, Waldo; Massardo, Loreto; Varela-Nallar, Lorena; González, AlfonsoItem Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEGEspinoza, Sofía; Arredondo, Sebastián B.; Barake, Francisca; Carvajal, Francisco; Guerrero, Fernanda G.; Segovia-Miranda, Fabian; Valenzuela, David M.; Wyneken, Úrsula; Rojas-Fernández, Alejandro; Cerpa, Waldo; Massardo, Loreto; Varela-Nallar, Lorena; González, AlfonsoItem Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEGEspinoza, Sofía; Arredondo, Sebastián B.; Barake, Francisca; Carvajal, Francisco; Guerrero, Fernanda G.; Segovia-Miranda, Fabian; Valenzuela, David M.; Wyneken, Úrsula; Rojas-Fernández, Alejandro; Cerpa, Waldo; Massardo, Loreto; Varela-Nallar, Lorena; González, AlfonsoItem Neuropilin-1 is present on Foxp3+ T regulatory cell-derived small extracellular vesicles and mediates immunity against skin transplantationCampos-Mora, Mauricio; De Solminihac, Javiera; Rojas, Carolina; Padilla, Cristina; Kurte, Mónica; Pacheco, Rodrigo; Kaehne, Thilo; Wyneken, Úrsula; Pino-Lagos, KarinaItem Neuropilin-1 is present on Foxp3+ T regulatory cell-derived small extracellular vesicles and mediates immunity against skin transplantationCampos-Mora, Mauricio; De Solminihac, Javiera; Rojas, Carolina; Padilla, Cristina; Kurte, Mónica; Pacheco, Rodrigo; Kaehne, Thilo; Wyneken, Úrsula; Pino-Lagos, KarinaItem Neuropilin-1 is present on Foxp3+ T regulatory cell-derived small extracellular vesicles and mediates immunity against skin transplantationCampos-Mora, Mauricio; De Solminihac, Javiera; Rojas, Carolina; Padilla, Cristina; Kurte, Mónica; Pacheco, Rodrigo; Kaehne, Thilo; Wyneken, Úrsula; Pino-Lagos, KarinaItem Wyneken, ÚrsulaWyneken, Úrsula