Browsing by Author "Nardocci, Gino"
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Item Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?Luarte, Alejandro; Nardocci, Gino; Chakraborty, Ankush; Batiz, Luis Federico; Pino-Lagos, Karina; Wyneken, ÚrsulaItem Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritisFigueroa-Valdés, Aliosha I.; Luz-Crawford, Patricia; Herrera-Luna, Yeimi; Georges-Calderón, Nicolás; García, Cynthia; Tobar, Hugo E.; Araya, María Jesús; Matas, José; Donoso-Meneses, Darío; de la Fuente, Catalina; Cuenca, Jimena; Parra, Eliseo; Lillo, Fernando; Varela, Cristóbal; Cádiz, María Ignacia; Vernal, Rolando; Ortloff, Alexander; Nardocci, Gino; Castañeda, Verónica; Adasme-Vidal, Catalina; Kunze-Küllmer, Maximiliano; Hidalgo, Yessia; Espinoza, Francisco; Khoury, Maroun; Alcayaga-Miranda, FranciscaItem Differential H3K4me3 Domains in Normal and Colorectal Cancer Cells Reveal Novel Epigenetic TargetsBahia, Ravinder Kaur; Lopez, Camila; Nardocci, Gino; Davie, James R.Item The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genesBeacon, Tasnim H.; Delcuve, Geneviève P.; López, Camila; Nardocci, Gino; Kovalchuk, Igor; van Wijnen, Andre J.; Davie, James R.Item Epigenetic control of osteogenic lineage commitmentMontecino, Martin; Carrasco, Margarita E.; Nardocci, GinoItem FOXM1 Participates in Trophoblast Migration and Early Trophoblast Invasion: potential Role in Blastocyst ImplantationPeñailillo, Reyna; Velásquez, Victoria; Acuña-Gallardo, Stephanie; García, Felipe; Sánchez, Mario; Nardocci, Gino; Illanes, Sebastián E.; Monteiro, Lara J.Item Identification of LOC101927355 as a Novel Biomarker for PreeclampsiaPeñailillo, Reyna; Monteiro, Lara J.; Acuña-Gallardo, Stephanie; García, Felipe; Velásquez, Victoria; Correa, Paula; Díaz, Pilar; Valdebenito, Patricia P.; Navarro, Cristina; Romero, Roberto; Sánchez, Mario; Illanes, Sebastián E.; Nardocci, GinoItem Impact of KDM6B mosaic brain knockout on synaptic function and behavior(Scientific Reports, 2024-12) Nardocci, GinoAutism spectrum disorders (ASD) are complex neurodevelopmental conditions characterized by impairments in social communication, repetitive behaviors, and restricted interests. Epigenetic modifications serve as critical regulators of gene expression playing a crucial role in controlling brain function and behavior. Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, has emerged as one of the highest ASD risk genes, but the precise effects of KDM6B mutations on neuronal activity and behavioral function remain elusive. Here we show the impact of KDM6B mosaic brain knockout on the manifestation of different autistic-like phenotypes including repetitive behaviors, social interaction, and significant cognitive deficits. Moreover, KDM6B mosaic knockout display abnormalities in hippocampal excitatory synaptic transmission decreasing NMDA receptor mediated synaptic transmission and plasticity. Understanding the intricate interplay between epigenetic modifications and neuronal function may provide novel insights into the pathophysiology of ASD and potentially inform the development of targeted therapeutic interventions.Item Impact of KDM6B mosaic brain knockout on synaptic function and behaviorBrauer, Bastian; Ancatén-González, Carlos; Ahumada-Marchant, Constanza; Meza, Rodrigo C.; Merino-Veliz, Nicolas; Nardocci, Gino; Varela-Nallar, Lorena; Arriagada, Gloria; Chávez, Andrés E.; Bustos, Fernando J.Item Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblastsCarrasco, Margarita E.; Thaler, Roman; Nardocci, Gino; Dudakovic, Amel; van Wijnen, Andre J.Item Inverse Modulation of Aurora Kinase A and Topoisomerase II? in Normal and Tumor Breast Cells upon Knockdown of Mitochondrial ASncmtRNABendek, Maximiliano F.; Fitzpatrick, Christopher; Jeldes, Emanuel; Boland, Anne; Deleuze, Jean François; Farfán, Nicole; Villegas, Jaime; Nardocci, Gino; Montecino, Martín; Burzio, Luis O.; Burzio, Verónica A.Item The key role of differential broad H3K4me3 and H3K4ac domains in breast cancerLópez, Camila; Barnon, Mohammad T.; Beacon, Tasnim H.; Nardocci, Gino; Davie, James R.Item Long Noncoding RNA TALAM1 Is a Transcriptional Target of the RUNX2 Transcription Factor in Lung AdenocarcinomaBermúdez, Gisella; Bernal, Camila; Otalora, Andrea; Sanchez, Paula; Nardocci, Gino; Cañas, Alejandra; Lopez-Kleine, Liliana; Montecino, Martín; Rojas, AdrianaItem Maternal plasma cell-free RNA as a predictive test for fetal lung maturationCarter, Sean W.D.; Seah, Kay Yi Michelle; Poh, Si En; Koh, Winston; Usuda, Haruo; Johnson, Erin L.; Kumagai, Yusaku; Takahashi, Tsukasa; Monteiro, Lara J.; Peñailillo, Reyna; Nardocci, Gino; Watson, Hannah R.S.; Saito, Masatoshi; Choolani, Mahesh A.; Illanes, Sebastián E.; Kemp, Matthew W.Item Mesenchymal Stem Cells-Induced Trophoblast Invasion Is Reduced in Patients with a Previous History of PreeclampsiaPeñailillo, Reyna; Acuña-Gallardo, Stephanie; García, Felipe; Monteiro, Lara J.; Nardocci, Gino; Choolani, Mahesh A.; Kemp, Matthew W.; Romero, Roberto; Illanes, Sebastián E.Item The Olfactory Organ Is a Unique Site for Neutrophils in the BrainPalominos, M. Fernanda; Calfún, Cristian; Nardocci, Gino; Candia, Danissa; Torres-Paz, Jorge; Whitlock, Kathleen E.Item Proteomic Insights Into Gingival Crevicular Extracellular Vesicles in Periodontitis and Gestational Diabetes: An Exploratory StudyMizgier, María Luisa; Nardocci, Gino; Ramírez, Valeria; Bendek, María José; Hernández, Marcela; Rojas, Carolina; Herrera, David; Kantarci, Alpdogan; Kemp, Matthew W.; Illanes, Sebastián E.; Chaparro, AlejandraItem An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutationsSegarra-Fas, Anna; Espejo-Serrano, Carmen; Bustos, Francisco; Zhou, Houjiang; Wang, Feng; Toth, Rachel; Macartney, Thomas; Bach, Ingolf; Nardocci, Gino; Findlay, Greg M.Item The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth RestrictionMonteiro, Lara; Peñailillo, Reyna; Sánchez, Mario; Acuña-Gallardo, Stephanie; Mönckeberg, Max; Ong, Judith; Choolani, Mahesh; Illanes, Sebastián; Nardocci, Gino