Browsing by Author "Khoury, Maroun"
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Item An advanced biphasic porous and injectable scaffold displays a fine balance between mechanical strength and remodeling capabilities essential for cartilage regenerationZavala, Gabriela; Viafara-García, Sergio M.; Novoa, Javier; Hidalgo, Carmen; Contardo, Ingrid; Díaz-Calderón, Paulo; Alejandro González-Arriagada, Wilfredo; Khoury, Maroun; Acevedo, Juan PabloItem An advanced biphasic porous and injectable scaffold displays a fine balance between mechanical strength and remodeling capabilities essential for cartilage regenerationZavala, Gabriela; Viafara-García, Sergio M.; Novoa, Javier; Hidalgo, Carmen; Contardo, Ingrid; Díaz-Calderón, Paulo; Alejandro González-Arriagada, Wilfredo; Khoury, Maroun; Acevedo, Juan PabloItem Allogeneic Cellular Therapy in a Mature Tooth with Apical Periodontitis and Accidental Root Perforation: A Case ReportCordero, Claudia Brizuela; Santander, Gaston Meza; González, Denisse Urrejola; Quezada, Andrea; Silva, Carolina Inostroza; Vásquez, Camila; Jara, Richard; Jara, Daniel; Khoury, MarounItem Allogeneic Cellular Therapy in a Mature Tooth with Apical Periodontitis and Accidental Root Perforation: A Case ReportCordero, Claudia Brizuela; Santander, Gaston Meza; González, Denisse Urrejola; Quezada, Andrea; Silva, Carolina Inostroza; Vásquez, Camila; Jara, Richard; Jara, Daniel; Khoury, MarounItem Antimicrobial activity of mesenchymal stem cells: Current status and new perspectives of antimicrobial peptide-based therapies(30-03-2017) Alcayaga-Miranda, Francisca; Cuenca, Jimena; Khoury, MarounWhile mesenchymal stem cells (MSCs)-based therapy appears to be promising, there are concerns regarding possible side effects related to the unwanted suppression of antimicrobial immunity leading to an increased risk of infection. Conversely, recent data show that MSCs exert strong antimicrobial effects through indirect and direct mechanisms, partially mediated by the secretion of antimicrobial peptides and proteins (AMPs). In fact, MSCs have been reported to increase bacterial clearance in preclinical models of sepsis, acute respiratory distress syndrome, and cystic fibrosis-related infections. This article reviews the current evidence regarding the direct antimicrobial effector function of MSCs, focusing mainly on the role of MSCs-derived AMPs. The strategies that might modulate the expression and secretion of these AMPs, leading to enhanced antimicrobial effect, are highlighted. Furthermore, studies evaluating the presence of AMPs in the cargo of extracellular vesicles (EVs) are underlined as perspective opportunities to develop new drug delivery tools. The antimicrobial potential of MSCs-derived EVs can also be heightened through cell conditioning and/or drug loading. Finally, improving the pharmacokinetics and delivery, in addition to deciphering the multi-target drug status of AMPs, should synergistically lead to key advances against infections caused by drug-resistant strains.Item The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potentialContreras-Lopez, Rafael; Elizondo-Vega, Roberto; Luque-Campos, Noymar; Torres, María José; Pradenas, Carolina; Tejedor, Gautier; Paredes-Martínez, María José; Vega-Letter, Ana María; Campos-Mora, Mauricio; Rigual-Gonzalez, Yandi; Oyarce, Karina; Salgado, Magdiel; Jorgensen, Christian; Khoury, Maroun; Garcia-Robles, María de los Ángeles; Altamirano, Claudia; Djouad, Farida; Luz-Crawford, PatriciaItem The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potentialContreras-Lopez, Rafael; Elizondo-Vega, Roberto; Luque-Campos, Noymar; Torres, María José; Pradenas, Carolina; Tejedor, Gautier; Paredes-Martínez, María José; Vega-Letter, Ana María; Campos-Mora, Mauricio; Rigual-Gonzalez, Yandi; Oyarce, Karina; Salgado, Magdiel; Jorgensen, Christian; Khoury, Maroun; Garcia-Robles, María de los Ángeles; Altamirano, Claudia; Djouad, Farida; Luz-Crawford, PatriciaItem The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potentialContreras-Lopez, Rafael; Elizondo-Vega, Roberto; Luque-Campos, Noymar; Torres, María José; Pradenas, Carolina; Tejedor, Gautier; Paredes-Martínez, María José; Vega-Letter, Ana María; Campos-Mora, Mauricio; Rigual-Gonzalez, Yandi; Oyarce, Karina; Salgado, Magdiel; Jorgensen, Christian; Khoury, Maroun; Garcia-Robles, María de los Ángeles; Altamirano, Claudia; Djouad, Farida; Luz-Crawford, PatriciaItem Author Correction: Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries (Nature Communications, (2019), 10, 1, (3098), 10.1038/s41467-019-11090-3)Akentjew, Tamara L.; Terraza, Claudia; Suazo, Cristian; Maksimcuka, Jekaterina; Wilkens, Camila A.; Vargas, Francisco; Zavala, Gabriela; Ocaña, Macarena; Enrione, Javier; García-Herrera, Claudio M.; Valenzuela, Loreto M.; Blaker, Jonny J.; Khoury, Maroun; Acevedo, Juan PabloItem Author Correction: Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries (Nature Communications, (2019), 10, 1, (3098), 10.1038/s41467-019-11090-3)Akentjew, Tamara L.; Terraza, Claudia; Suazo, Cristian; Maksimcuka, Jekaterina; Wilkens, Camila A.; Vargas, Francisco; Zavala, Gabriela; Ocaña, Macarena; Enrione, Javier; García-Herrera, Claudio M.; Valenzuela, Loreto M.; Blaker, Jonny J.; Khoury, Maroun; Acevedo, Juan PabloItem Author Correction: Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries (Nature Communications, (2019), 10, 1, (3098), 10.1038/s41467-019-11090-3)Akentjew, Tamara L.; Terraza, Claudia; Suazo, Cristian; Maksimcuka, Jekaterina; Wilkens, Camila A.; Vargas, Francisco; Zavala, Gabriela; Ocaña, Macarena; Enrione, Javier; García-Herrera, Claudio M.; Valenzuela, Loreto M.; Blaker, Jonny J.; Khoury, Maroun; Acevedo, Juan PabloItem Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essentialKhoury, Maroun; Rocco, Patricia R.M.; Phinney, Donald G.; Krampera, Mauro; Martin, Ivan; Viswanathan, Sowmya; Nolta, Jan A.; LeBlanc, Katarina; Galipeau, Jacques; Weiss, Daniel J.Item Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essentialKhoury, Maroun; Rocco, Patricia R.M.; Phinney, Donald G.; Krampera, Mauro; Martin, Ivan; Viswanathan, Sowmya; Nolta, Jan A.; LeBlanc, Katarina; Galipeau, Jacques; Weiss, Daniel J.Item Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essentialKhoury, Maroun; Rocco, Patricia R.M.; Phinney, Donald G.; Krampera, Mauro; Martin, Ivan; Viswanathan, Sowmya; Nolta, Jan A.; LeBlanc, Katarina; Galipeau, Jacques; Weiss, Daniel J.Item A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem CellsFigueroa-Valdés, Aliosha I.; de la Fuente, Catalina; Hidalgo, Yessia; Vega-Letter, Ana María; Tapia-Limonchi, Rafael; Khoury, Maroun; Alcayaga Miranda, FranciscaItem A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem CellsFigueroa-Valdés, Aliosha I.; de la Fuente, Catalina; Hidalgo, Yessia; Vega-Letter, Ana María; Tapia-Limonchi, Rafael; Khoury, Maroun; Alcayaga Miranda, FranciscaItem A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem CellsFigueroa-Valdés, Aliosha I.; de la Fuente, Catalina; Hidalgo, Yessia; Vega-Letter, Ana María; Tapia-Limonchi, Rafael; Khoury, Maroun; Alcayaga Miranda, FranciscaItem Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritisFigueroa-Valdés, Aliosha I.; Luz-Crawford, Patricia; Herrera-Luna, Yeimi; Georges-Calderón, Nicolás; García, Cynthia; Tobar, Hugo E.; Araya, María Jesús; Matas, José; Donoso-Meneses, Darío; de la Fuente, Catalina; Cuenca, Jimena; Parra, Eliseo; Lillo, Fernando; Varela, Cristóbal; Cádiz, María Ignacia; Vernal, Rolando; Ortloff, Alexander; Nardocci, Gino; Castañeda, Verónica; Adasme-Vidal, Catalina; Kunze-Küllmer, Maximiliano; Hidalgo, Yessia; Espinoza, Francisco; Khoury, Maroun; Alcayaga-Miranda, FranciscaItem Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritisFigueroa-Valdés, Aliosha I.; Luz-Crawford, Patricia; Herrera-Luna, Yeimi; Georges-Calderón, Nicolás; García, Cynthia; Tobar, Hugo E.; Araya, María Jesús; Matas, José; Donoso-Meneses, Darío; de la Fuente, Catalina; Cuenca, Jimena; Parra, Eliseo; Lillo, Fernando; Varela, Cristóbal; Cádiz, María Ignacia; Vernal, Rolando; Ortloff, Alexander; Nardocci, Gino; Castañeda, Verónica; Adasme-Vidal, Catalina; Kunze-Küllmer, Maximiliano; Hidalgo, Yessia; Espinoza, Francisco; Khoury, Maroun; Alcayaga-Miranda, FranciscaItem Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritisFigueroa-Valdés, Aliosha I.; Luz-Crawford, Patricia; Herrera-Luna, Yeimi; Georges-Calderón, Nicolás; García, Cynthia; Tobar, Hugo E.; Araya, María Jesús; Matas, José; Donoso-Meneses, Darío; de la Fuente, Catalina; Cuenca, Jimena; Parra, Eliseo; Lillo, Fernando; Varela, Cristóbal; Cádiz, María Ignacia; Vernal, Rolando; Ortloff, Alexander; Nardocci, Gino; Castañeda, Verónica; Adasme-Vidal, Catalina; Kunze-Küllmer, Maximiliano; Hidalgo, Yessia; Espinoza, Francisco; Khoury, Maroun; Alcayaga-Miranda, Francisca