Browsing by Author "Illanes, Sebastián E."
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Item Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturationCarter, Sean W.D.; Fee, Erin L.; Usuda, Haruo; Oguz, Gokce; Ramasamy, Adaikalavan; Amin, Zubair; Agnihotri, Biswas; Wei, Qin; Xiawen, Liu; Takahashi, Tsukasa; Takahashi, Yuki; Ikeda, Hideyuki; Kumagai, Yusaku; Saito, Yuya; Saito, Masatoshi; Mattar, Citra; Evans, Mark I.; Illanes, Sebastián E.; Jobe, Alan H.; Choolani, Mahesh; Kemp, Matthew W.Item Attitudes Toward Selective Abortion: The Role of Prenatal Diagnosis and PrognosisRodríguez, Cristián G.; Choolani, Mahesh; Illanes, Sebastián E.Item Cellular mechanisms linking to outdoor and indoor air pollution damage during pregnancyChiarello, Delia I.; Ustáriz, Javier; Marín, Reinaldo; Carrasco-Wong, Ivo; Farías, Marcelo; Giordano, Ady; Gallardo, Felipe S.; Illanes, Sebastián E.; Gutiérrez, JaimeItem Chorioamnionitis: An Update on Diagnostic EvaluationCarter, Sean W.D.; Neubronner, Samantha; Su, Lin Lin; Dashraath, Pradip; Mattar, Citra; Illanes, Sebastián E.; Choolani, Mahesh A.; Kemp, Matthew W.Item Climate change and preterm birth: A narrative reviewBátiz, Luis Federico; Illanes, Sebastián E.; Romero, Roberto; Barrera, María del Valle; Mattar, Citra N.Z.; Choolani, Mahesh A.; Kemp, Matthew W.Item Correction: Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation (BMC Medicine, (2024), 22, 1, (338), 10.1186/s12916-024-03542-5)Carter, Sean W.D.; Fee, Erin L.; Usuda, Haruo; Oguz, Gokce; Ramasamy, Adaikalavan; Amin, Zubair; Agnihotri, Biswas; Wei, Qin; Xiawen, Liu; Takahashi, Tsukasa; Takahashi, Yuki; Ikeda, Hideyuki; Kumagai, Yusaku; Saito, Yuya; Saito, Masatoshi; Mattar, Citra; Evans, Mark I.; Illanes, Sebastián E.; Jobe, Alan H.; Choolani, Mahesh; Kemp, Matthew W.Item Development and analytical validation of real-time PCR for the detection of Streptococcus agalactiae in pregnant womenEscobar, Daniel F.; Diaz-Dinamarca, Diego A.; Hernández, Carlos F.; Soto, Daniel A.; Manzo, Ricardo A.; Alarcón, Pedro I.; Pinto, Camila H.; Bastias, Diego N.; Oberg-Bravo, Carolayn N.; Rojas, Robert; Illanes, Sebastián E.; Kalergis, Alexis M.; Vasquez, Abel E.Item Diagnostic performance of first trimester screening of preeclampsia based on uterine artery pulsatility index and maternal risk factors in routine clinical use.Mönckeberg, Max; Arias, Valentina; Fuenzalida, Rosario; Álvarez, Santiago; Toro, Victoria; Calvo, Andrés; Kusanovic, Juan P.; Monteiro, Lara J.; Schepeler, Manuel; Nien, Jyh K.; Martinez, Jaime; Illanes, Sebastián E.Item Disruption of LDL receptor trafficking in placentas from maternal supraphysiological hypercholesterolemia: A study of key endocytosis and recycling proteinsMorales, Andrea; Riquelme, Nicolás; Illanes, Sebastián E.; Leiva, AndreaItem Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and -9 are associated with the severity of periodontitis and the development of gestational diabetes mellitusChaparro, Alejandra; Realini, Ornella; Hernández, Marcela; Albers, Daniela; Weber, Laura; Ramírez, Valeria; Param, Fernanda; Kusanovic, Juan Pedro; Sorsa, Timo; Rice, Gregory Edward; Illanes, Sebastián E.Item Effect of prenatal omega 3 supplementation on pregnancy outcomesPeñailillo, Reyna; Plaza, Alejandra; Díaz, Claudio; Lagos, Matías; Barros, Antonia; Illanes, Sebastián E.Item FOXM1 Participates in Trophoblast Migration and Early Trophoblast Invasion: potential Role in Blastocyst ImplantationPeñailillo, Reyna; Velásquez, Victoria; Acuña-Gallardo, Stephanie; García, Felipe; Sánchez, Mario; Nardocci, Gino; Illanes, Sebastián E.; Monteiro, Lara J.Item Identification of LOC101927355 as a Novel Biomarker for PreeclampsiaPeñailillo, Reyna; Monteiro, Lara J.; Acuña-Gallardo, Stephanie; García, Felipe; Velásquez, Victoria; Correa, Paula; Díaz, Pilar; Valdebenito, Patricia P.; Navarro, Cristina; Romero, Roberto; Sánchez, Mario; Illanes, Sebastián E.; Nardocci, GinoItem Increased Circulating Levels of PCSK9 and Pro-Atherogenic Lipoprotein Profile in Pregnant Women with Maternal Supraphysiological HypercholesterolemiaCantin, Claudette; Garchitorena, María Jesús; Escalona, Rodrigo; Carvajal, Jorge A.; Illanes, Sebastián E.; Gutierrez, Jaime; Leiva, AndreaItem Increased circulating levels of tissue-type plasminogen activator are associated with the risk of spontaneous abortion during the first trimester of pregnancy.Monteiro, Lara J.; Varas-Godoy, Manuel; Acuña-Gallardo, Stephanie; Correa, Paula; Passalacqua, Gianluca; Monckeberg, Max; Rice, Gregory E.; Illanes, Sebastián E.Item Maternal plasma cell-free RNA as a predictive test for fetal lung maturationCarter, Sean W.D.; Seah, Kay Yi Michelle; Poh, Si En; Koh, Winston; Usuda, Haruo; Johnson, Erin L.; Kumagai, Yusaku; Takahashi, Tsukasa; Monteiro, Lara J.; Peñailillo, Reyna; Nardocci, Gino; Watson, Hannah R.S.; Saito, Masatoshi; Choolani, Mahesh A.; Illanes, Sebastián E.; Kemp, Matthew W.Item Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus(Biological Research, 2024-12) Sánchez Rubio, Mario; Abarzúa Catalán, Lorena; Del Valle, Ana; Méndez Ruette, Maxs; Salazar, Natalia; Sigala, Jacinta; Sandoval, Soledad; Luarte, Alejandro; Monteiro, Lara J.; Wyneken, Úrsula; Illanes, Sebastián E.; Bátiz, Luis FedericoBackground: Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting consequences for the offspring. These effects show a sex bias. The mechanisms whereby prenatal stress induces functional and/or structural changes in the placental-fetal unit remain poorly understood. Maternal circulating small extracellular vesicles (sEVs) are good candidates to act as “stress signals” in mother-to-fetus communication. Using a repetitive restraint-based rat model of prenatal stress, we examined circulating maternal sEVs under stress conditions and tested whether they could target placental-fetal tissues. Results: Our mild chronic maternal stress during pregnancy paradigm induced anhedonic-like behavior in pregnant dams and led to intrauterine growth restriction (IUGR), particularly in male fetuses and placentas. The concentration and cargo of maternal circulating sEVs changed under stress conditions. Specifically, there was a significant reduction in neuron-enriched proteins and a significant increase in astrocyte-enriched proteins in blood-borne sEVs from stressed dams. To study the effect of repetitive restraint stress on the biodistribution of maternal circulating sEVs in the fetoplacental unit, sEVs from pregnant dams exposed to stress or control protocol were labeled with DiR fluorescent die and injected into pregnant females previously exposed to control or stress protocol. Remarkably, maternal circulating sEVs target placental/fetal tissues and, under stress conditions, fetal tissues are more receptive to sEVs. Conclusion: Our results suggest that maternal circulating sEVs can act as novel mediators/modulators of mother-to-fetus stress communication. Further studies are needed to identify placental/fetal cellular targets of maternal sEVs and characterize their contribution to stress-induced sex-specific placental and fetal changes.Item Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetusSánchez-Rubio, Mario; Abarzúa-Catalán, Lorena; del Valle, Ana; Méndez-Ruette, Maxs; Salazar, Natalia; Sigala, Jacinta; Sandoval, Soledad; Godoy, María Inés; Luarte, Alejandro; Monteiro, Lara J.; Romero, Roberto; Choolani, Mahesh A.; Wyneken, Úrsula; Illanes, Sebastián E.; Bátiz, Luis FedericoItem Maternal Supraphysiological Hypercholesterolemia Is Accompanied by Shifts in the Composition and Anti-Atherogenic Functions of Maternal HDL along with Maternal Cardiovascular Risk Markers at Term of PregnancyCantin, Claudette; Morales, Andrea; Serra, Ramón; Illanes, Sebastián E.; Leiva, AndreaItem Mesenchymal Stem Cells-Induced Trophoblast Invasion Is Reduced in Patients with a Previous History of PreeclampsiaPeñailillo, Reyna; Acuña-Gallardo, Stephanie; García, Felipe; Monteiro, Lara J.; Nardocci, Gino; Choolani, Mahesh A.; Kemp, Matthew W.; Romero, Roberto; Illanes, Sebastián E.