Browsing by Author "Cuenca, Jimena"
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Item Antimicrobial activity of mesenchymal stem cells: Current status and new perspectives of antimicrobial peptide-based therapies(30-03-2017) Alcayaga-Miranda, Francisca; Cuenca, Jimena; Khoury, MarounWhile mesenchymal stem cells (MSCs)-based therapy appears to be promising, there are concerns regarding possible side effects related to the unwanted suppression of antimicrobial immunity leading to an increased risk of infection. Conversely, recent data show that MSCs exert strong antimicrobial effects through indirect and direct mechanisms, partially mediated by the secretion of antimicrobial peptides and proteins (AMPs). In fact, MSCs have been reported to increase bacterial clearance in preclinical models of sepsis, acute respiratory distress syndrome, and cystic fibrosis-related infections. This article reviews the current evidence regarding the direct antimicrobial effector function of MSCs, focusing mainly on the role of MSCs-derived AMPs. The strategies that might modulate the expression and secretion of these AMPs, leading to enhanced antimicrobial effect, are highlighted. Furthermore, studies evaluating the presence of AMPs in the cargo of extracellular vesicles (EVs) are underlined as perspective opportunities to develop new drug delivery tools. The antimicrobial potential of MSCs-derived EVs can also be heightened through cell conditioning and/or drug loading. Finally, improving the pharmacokinetics and delivery, in addition to deciphering the multi-target drug status of AMPs, should synergistically lead to key advances against infections caused by drug-resistant strains.Item Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritisFigueroa-Valdés, Aliosha I.; Luz-Crawford, Patricia; Herrera-Luna, Yeimi; Georges-Calderón, Nicolás; García, Cynthia; Tobar, Hugo E.; Araya, María Jesús; Matas, José; Donoso-Meneses, Darío; de la Fuente, Catalina; Cuenca, Jimena; Parra, Eliseo; Lillo, Fernando; Varela, Cristóbal; Cádiz, María Ignacia; Vernal, Rolando; Ortloff, Alexander; Nardocci, Gino; Castañeda, Verónica; Adasme-Vidal, Catalina; Kunze-Küllmer, Maximiliano; Hidalgo, Yessia; Espinoza, Francisco; Khoury, Maroun; Alcayaga-Miranda, FranciscaItem Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritisFigueroa-Valdés, Aliosha I.; Luz-Crawford, Patricia; Herrera-Luna, Yeimi; Georges-Calderón, Nicolás; García, Cynthia; Tobar, Hugo E.; Araya, María Jesús; Matas, José; Donoso-Meneses, Darío; de la Fuente, Catalina; Cuenca, Jimena; Parra, Eliseo; Lillo, Fernando; Varela, Cristóbal; Cádiz, María Ignacia; Vernal, Rolando; Ortloff, Alexander; Nardocci, Gino; Castañeda, Verónica; Adasme-Vidal, Catalina; Kunze-Küllmer, Maximiliano; Hidalgo, Yessia; Espinoza, Francisco; Khoury, Maroun; Alcayaga-Miranda, FranciscaItem Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritisFigueroa-Valdés, Aliosha I.; Luz-Crawford, Patricia; Herrera-Luna, Yeimi; Georges-Calderón, Nicolás; García, Cynthia; Tobar, Hugo E.; Araya, María Jesús; Matas, José; Donoso-Meneses, Darío; de la Fuente, Catalina; Cuenca, Jimena; Parra, Eliseo; Lillo, Fernando; Varela, Cristóbal; Cádiz, María Ignacia; Vernal, Rolando; Ortloff, Alexander; Nardocci, Gino; Castañeda, Verónica; Adasme-Vidal, Catalina; Kunze-Küllmer, Maximiliano; Hidalgo, Yessia; Espinoza, Francisco; Khoury, Maroun; Alcayaga-Miranda, FranciscaItem Cuenca, JimenaCuenca, JimenaItem Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19Khoury, Maroun; Cuenca, Jimena; Cruz, Fernanda F.; Figueroa, Fernando E.; Rocco, Patricia R.M.; Weiss, Daniel J.Item Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19Khoury, Maroun; Cuenca, Jimena; Cruz, Fernanda F.; Figueroa, Fernando E.; Rocco, Patricia R.M.; Weiss, Daniel J.Item Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19Khoury, Maroun; Cuenca, Jimena; Cruz, Fernanda F.; Figueroa, Fernando E.; Rocco, Patricia R.M.; Weiss, Daniel J.Item Delivery of affordable and scalable encapsulated allogenic/autologous mesenchymal stem cells in coagulated platelet poor plasma for dental pulp regenerationAngelopoulos, Ioannis; Trigo, Cesar; Ortuzar, Maria Ignacia; Cuenca, Jimena; Brizuela, Claudia; Khoury, MarounItem Delivery of affordable and scalable encapsulated allogenic/autologous mesenchymal stem cells in coagulated platelet poor plasma for dental pulp regenerationAngelopoulos, Ioannis; Trigo, Cesar; Ortuzar, Maria Ignacia; Cuenca, Jimena; Brizuela, Claudia; Khoury, MarounItem Delivery of affordable and scalable encapsulated allogenic/autologous mesenchymal stem cells in coagulated platelet poor plasma for dental pulp regenerationAngelopoulos, Ioannis; Trigo, Cesar; Ortuzar, Maria Ignacia; Cuenca, Jimena; Brizuela, Claudia; Khoury, MarounItem A novel porous hydrogel based on hybrid gelation for injectable and tough scaffold implantation and tissue engineering applicationsHidalgo, Carmen; Méndez-Ruette, Maxs; Zavala, Gabriela; Viafara-García, Sergio; Novoa, Javier; Díaz-Calderón, Paulo; González-Arriagada, Wilfredo Alejandro; Cuenca, Jimena; Khoury, Maroun; Acevedo Cox, Juan PabloItem A novel porous hydrogel based on hybrid gelation for injectable and tough scaffold implantation and tissue engineering applicationsHidalgo, Carmen; Méndez-Ruette, Maxs; Zavala, Gabriela; Viafara-García, Sergio; Novoa, Javier; Díaz-Calderón, Paulo; González-Arriagada, Wilfredo Alejandro; Cuenca, Jimena; Khoury, Maroun; Acevedo Cox, Juan PabloItem A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee OsteoarthritisMatas, Jose; García, Cynthia; Poblete, Daniela; Vernal, Rolando; Ortloff, Alexander; Luque-Campos, Noymar; Hidalgo, Yessia; Cuenca, Jimena; Infante, Catalina; Cadiz, Maria Ignacia; Khoury, Maroun; Luz-Crawford, Patricia; Espinoza, FranciscoItem A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee OsteoarthritisMatas, Jose; García, Cynthia; Poblete, Daniela; Vernal, Rolando; Ortloff, Alexander; Luque-Campos, Noymar; Hidalgo, Yessia; Cuenca, Jimena; Infante, Catalina; Cadiz, Maria Ignacia; Khoury, Maroun; Luz-Crawford, Patricia; Espinoza, FranciscoItem A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee OsteoarthritisMatas, Jose; García, Cynthia; Poblete, Daniela; Vernal, Rolando; Ortloff, Alexander; Luque-Campos, Noymar; Hidalgo, Yessia; Cuenca, Jimena; Infante, Catalina; Cadiz, Maria Ignacia; Khoury, Maroun; Luz-Crawford, Patricia; Espinoza, FranciscoItem A Psychrophilic GelMA: Breaking Technical and Immunological Barriers for Multimaterial High-Resolution 3D BioprintingZaupa, Alessandro; Terraza, Claudia; Abarzúa-Illanes, Phammela N.; Byres, Nicholas; Zavala, Gabriela; Cuenca, Jimena; Hidalgo, Carmen; Viafara-Garcia, Sergio M.; Wolf, Bettina; Pino-Lagos, Karina; Blaker, Jonny J.; Rumbak, Mayan; Khoury, Maroun; Enrione, Javier; Acevedo, Juan PabloItem A Psychrophilic GelMA: Breaking Technical and Immunological Barriers for Multimaterial High-Resolution 3D BioprintingZaupa, Alessandro; Terraza, Claudia; Abarzúa-Illanes, Phammela N.; Byres, Nicholas; Zavala, Gabriela; Cuenca, Jimena; Hidalgo, Carmen; Viafara-Garcia, Sergio M.; Wolf, Bettina; Pino-Lagos, Karina; Blaker, Jonny J.; Rumbak, Mayan; Khoury, Maroun; Enrione, Javier; Acevedo, Juan PabloItem A Psychrophilic GelMA: Breaking Technical and Immunological Barriers for Multimaterial High-Resolution 3D BioprintingZaupa, Alessandro; Terraza, Claudia; Abarzúa-Illanes, Phammela N.; Byres, Nicholas; Zavala, Gabriela; Cuenca, Jimena; Hidalgo, Carmen; Viafara-Garcia, Sergio M.; Wolf, Bettina; Pino-Lagos, Karina; Blaker, Jonny J.; Rumbak, Mayan; Khoury, Maroun; Enrione, Javier; Acevedo, Juan PabloItem Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndromeAlcayaga-Miranda, Francisca; Dutra Silva, Johnatas; Parada, Nicol; Andrade da Silva, Luisa Helena; Ferreira Cruz, Fernanda; Utreras, Yildy; Hidalgo, Yessia; Cádiz, María Ignacia; Tapia Limonchi, Rafael; Espinoza, Francisco; Bruhn, Alejandro; Khoury, Maroun; R. M. Rocco, Patricia; Cuenca, Jimena